IL-1α modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil.
IL-1α modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil.
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DOI：
10.4049/jimmunol.1001328
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发表时间：
2011-02-01
期刊：
影响因子：
--
通讯作者：
Reeves WH
中科院分区：
文献类型：
--
作者：
Lee PY;Kumagai Y;Xu Y;Li Y;Barker T;Liu C;Sobel ES;Takeuchi O;Akira S;Satoh M;Reeves WH
暴露于天然碳氢油与人类和动物模型中慢性炎症的发生以及广泛的病理学发现有关。碳氢化合物引起的持续炎症反应的机制在很大程度上仍不清楚。中长链烷烃2，6，10，14四甲基十五烷（TMPD;也称为降植烷）是一种碳氢化合物，可有效缓解慢性腹膜炎，其特征为中性粒细胞和单核细胞的持续浸润。在这项研究中，我们揭示了白细胞介素（IL）-1α在TMPD治疗后维持中性粒细胞慢性募集中的重要作用。IL-1α和IL-1受体信号传导以CXC趋化因子受体-2（CXCR 2）依赖性方式促进中性粒细胞向腹膜腔迁移。这种机制至少部分依赖于中性粒细胞趋化因子CXCL 5的产生。此外，尽管炎性单核细胞的慢性浸润依赖于需要Toll样受体（TLR）-7、I型干扰素受体和CC-趋化因子受体-2（CCR 2）的不同途径，但衔接分子MyD 88、IRAK-4、IRAK 1和IRAK 2在调节单核细胞和中性粒细胞的募集中是共享的。总之，我们的研究结果揭示了碳氢化合物诱导的腹膜炎中中性粒细胞募集的IL-1α依赖性机制，并说明了慢性炎症中先天免疫途径的相互作用。
Exposure to naturally-occurring hydrocarbon oils is associated with the development of chronic inflammation and a wide spectrum of pathological findings in humans and animal models. The mechanism underlying the unremitting inflammatory response to hydrocarbons remains largely unclear. The medium-length alkane 2,6,10,14 tetramethylpentadecane (TMPD; also known as pristane) is a hydrocarbon that potently elicits chronic peritonitis characterized by persistent infiltration of neutrophils and monocytes. In this study, we reveal the essential role of interleukin (IL)-1α in sustaining the chronic recruitment of neutrophils following TMPD treatment. IL-1α and IL-1 receptor signaling promote the migration of neutrophils to the peritoneal cavity in a CXC chemokine receptor-2 (CXCR2)-dependent manner. This mechanism is at least partially dependent on the production of the neutrophil chemoattractant CXCL5. Moreover, although chronic infiltration of inflammatory monocytes is dependent on a different pathway requiring Toll-like receptor (TLR)-7, type-I interferon receptor, and CC-chemokine receptor-2 (CCR2), the adaptor molecules MyD88, IRAK-4, IRAK1 and IRAK2 are shared in regulating the recruitment of both monocytes and neutrophils. Taken together, our findings uncover an IL-1α-dependent mechanism of neutrophil recruitment in hydrocarbon-induced peritonitis and illustrate the interactions of innate immune pathways in chronic inflammation.
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DOI：
10.4049/jimmunol.179.7.4849
发表时间：
2007-10-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Duchene J;Lecomte F;Ahmed S;Cayla C;Pesquero J;Bader M;Perretti M;Ahluwalia A
通讯作者：
Ahluwalia A
影响因子：
82.9
作者：
Chen, Chun-Jen;Kono, Hajime;Rock, Kenneth L.
通讯作者：
Rock, Kenneth L.
影响因子：
--
作者：
Grespan, Renata;Fukada, Sandra Y.;Cunha, Fernando Q.
通讯作者：
Cunha, Fernando Q.
影响因子：
15.3
作者：
CANCRO, M;POTTER, M
通讯作者：
POTTER, M
DOI：
10.1006/bbrc.1994.2709
发表时间：
1994-11-30
影响因子：
3.1
作者：
CORBETT, MS;SCHMITT, I;WALZ, A
通讯作者：
WALZ, A