High-content screening in microfluidic devices.
High-content screening in microfluidic devices.
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DOI：
10.1517/17460441.2010.495116
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发表时间：
2010-08
影响因子：
6.3
通讯作者：
Levchenko A
中科院分区：
文献类型：
--
作者：
Cheong R;Paliwal S;Levchenko A
Miniaturization is key to advancing the state-of-the-art in high content screening (HCS), in order to enable dramatic cost savings through reduced usage of expensive biochemical reagents and to enable large-scale screening on primary cells. Microfluidic technology offers the potential to enable HCS to be performed with an unprecedented degree of miniaturization. This perspective highlights a real-world example from the authors’ work of HCS assays implemented in a highly miniaturized microfluidic format. Advantages of this technology are discussed, including cost savings, high throughput screening on primary cells, improved accuracy, the ability to study complex time-varying stimuli, and ease of automation, integration, and scaling. The reader will understand the capabilities of a new microfluidics-based platform for HCS, and the advantages it provides over conventional plate-based HCS. Microfluidics technology will drive significant advancements and broader usage and applicability of HCS in drug discovery.
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影响因子：
56.9
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通讯作者：
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