Stem cells for augmenting tendon repair.

Stem cells for augmenting tendon repair.
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DOI:
10.1155/2012/291431
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发表时间:
2012
影响因子:
4.3
通讯作者:
Wiznia D
Wiznia D
中科院分区:
医学3区
文献类型:
--
作者:
Gulotta LV;Chaudhury S;Wiznia D

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肌腱愈合充满了并发症,如再破裂和粘连形成,这是由于在损伤部位形成瘢痕组织而不是天然组织的再生。干细胞是开发基于细胞的治疗以改善肌腱愈合的一个有吸引力的选择。然而,在干细胞可以用于临床之前,还有几个问题需要回答。具体而言,干细胞的类型,细胞的数量,以及诱导分化的生长因子或机械刺激的适当组合都有待观察。本文概述了目前的文献中使用的干细胞肌腱扩增。
Tendon healing is fraught with complications such as reruptures and adhesion formation due to the formation of scar tissue at the injury site as opposed to the regeneration of native tissue. Stem cells are an attractive option in developing cell-based therapies to improve tendon healing. However, several questions remain to be answered before stem cells can be used clinically. Specifically, the type of stem cell, the amount of cells, and the proper combination of growth factors or mechanical stimuli to induce differentiation all remain to be seen. This paper outlines the current literature on the use of stem cells for tendon augmentation.
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