Monitoring for compliance with a ketogenic diet: what is the best time of day to test for urinary ketosis?
Monitoring for compliance with a ketogenic diet: what is the best time of day to test for urinary ketosis?
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DOI：
10.1186/s12986-016-0136-4
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发表时间：
2016
影响因子：
4.5
通讯作者：
Bertz H
中科院分区：
文献类型：
--
作者：
Urbain P;Bertz H
生酮饮食（KD）是一种非常低碳水化合物、高脂肪和足够蛋白质的饮食，没有热量限制，可诱导称为“生理性酮症”的代谢状况。它在20世纪20年代首次被引入治疗癫痫，最近作为减肥和提高性能的饮食变得非常流行。它在一系列疾病中的治疗用途正在调查中。在KD干预期间，人们应该通过每日尿酮检测来监测饮食方案的依从性。然而，没有研究调查测试的最佳时间。指导12名健康受试者（37 ± 11岁; BMI = 23.0 ± 2.5 kg/m2）在KD的第6周期间和稳定酮症期间，在24小时内定期测量其尿（8×）和血（18×）酮浓度。根据他们的1天食物记录，受试者平均消耗的饮食中脂肪、蛋白质和碳水化合物分别占总能量摄入的74.3 ± 4.0%、19.5 ± 3.5%和6.2 ± 2.0%。血β-羟基丁酸（BHB）（0.33 ± 0.17 mmol/l）和尿乙酰乙酸（AA）（0.46 ± 0.54 mmol/l）浓度最低值分别在10：00测量。分别在03：00观察到最高BHB（0.70 ± 0.62 mmol/l）和AA浓度。通过尿液检测，发现22：00和03：00时酮症水平最高，酮症的最高检出率（> 90%）分别为07：00、22：00和03：00。这些结果表明，稳定酮症受试者的酮尿最高，并且可以在清晨和晚餐后的尿液中最可靠地检测到。在未来的KD研究中，可以给出关于测量尿液中酮体的精确时间的建议。
The ketogenic diet (KD) is a very low-carbohydrate, high-fat and adequate-protein diet with no calorie limit that induces a metabolic condition called “physiological ketosis”. It was first introduced to treat epilepsy in the 1920s and has become quite popular recently as weight-loss and performance-enhancing diet. Its therapeutic use in a range of diseases is under investigation. During KD interventions people are supposed to monitor compliance with the dietary regimen by daily urine testing for ketosis. However, there are no studies investigating the best time for testing. Twelve healthy subjects (37 ± 11 years; BMI = 23.0 ± 2.5 kg/m2) were instructed to, during the sixth week of a KD and with stable ketosis, measure their urine (8×) and blood (18×) ketone concentration at regular intervals during a 24-h period. According to their 1-day food record, the subjects consumed on average a diet with 74.3 ± 4.0 %, 19.5 ± 3.5 %, and 6.2 ± 2.0 % of total energy intake from fat, protein and carbohydrate, respectively. The lowest blood ß-hydroxybutyrate (BHB) (0.33 ± 0.17 mmol/l) and urine acetoacetate (AA) (0.46 ± 0.54 mmol/l) concentrations were measured at 10:00, respectively. The highest BHB (0.70 ± 0.62 mmol/l) and AA concentrations were noted at 03:00, respectively. Via urine testing the highest levels of ketosis were found at 22:00 and 03:00 and the highest detection rates (>90 %) for ketosis were at 07:00, 22:00 and 03:00, respectively. These results indicate that ketonuria in subjects with stable ketosis is highest and can be most reliably detected in the early morning and post-dinner urine. Recommendations can be given regarding precise time of the day for measuring ketone bodies in urine in future studies with KDs.
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影响因子：
39.2
作者：
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通讯作者：
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DOI：
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