Visinin-like proteins (VSNLs): interaction partners and emerging functions in signal transduction of a subfamily of neuronal Ca2+ -sensor proteins.
Visinin-like proteins (VSNLs): interaction partners and emerging functions in signal transduction of a subfamily of neuronal Ca2+ -sensor proteins.
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DOI：
10.1007/s00441-008-0716-3
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发表时间：
2009-02
影响因子：
3.6
通讯作者：
Klein-Szanto AJ
中科院分区：
文献类型：
--
作者：
Braunewell KH;Klein-Szanto AJ
视神经素样蛋白（visin-like protein，VSNL）亚家族包括创始蛋白VILIP-1、VILIP-2、VILIP-3、神经钙蛋白（neurocalcin）和神经钙蛋白δ（neurocalcin δ），是一个高度同源的神经元钙感受器（neuronal calcium sensor，NCS）蛋白亚家族。比较研究表明，VSNL主要在脑中表达，在不同的神经元亚群中具有有限的表达模式，但也在外周器官中发现。此外，这些蛋白质在它们的钙亲和力、它们的膜结合动力学和它们在钙结合后与之缔合的细胞内靶标方面显示出差异。尽管这些蛋白质使用类似的钙-肉豆蔻酰转换机制易位到细胞膜，但当在同一神经元中表达时，它们显示钙依赖性定位到不同的亚细胞区室。这些独特的钙-肉豆蔻酰开关特性可以通过对定义的磷脂和膜结合靶点的特异性来解释，这使得VSNL能够调节各种细胞信号转导途径，包括环核苷酸和MAPK信号传导。一个新出现的主题是VSNLs对基因表达的直接或间接影响以及与膜运输复合物组分的相互作用，所述膜运输复合物组分可确定不同受体和离子通道（例如红藻氨酸和AMPA亚型的谷氨酸受体、烟碱ACh受体和Ca 2+通道）在膜运输中的作用。一种假设是，高度同源的VSNL已经进化为在膜运输中实现专门的功能，从而影响神经元信号传导和在限定的神经元亚群中的分化。VSNL参与分化过程，在外周器官中显示肿瘤侵袭抑制功能。最后，VSNLs发挥神经保护和神经毒性作用，并与神经退行性疾病有关。
The visinin-like protein (VSNL) subfamily, including the founder protein VILIP-1, VILIP-2, VILIP-3, hippocalcin and neurocalcin δ, constitute a highly homologous subfamily of neuronal calcium sensor (NCS) proteins. Comparative studies have shown that VSNLs are expressed predominantly in the brain with restricted expression patterns in different subsets of neurons, but are also found in peripheral organs. In addition, the proteins display differences in their calcium affinities, their membrane binding kinetics and in the intracellular targets to which they associate after calcium binding. Even though the proteins use a similar calcium-myristoyl switch mechanism to translocate to cellular membranes, they show calcium-dependent localization to different subcellular compartments when expressed in the same neuron. These distinct calcium-myristoyl switch properties might be explained by specificity for defined phospholipids and membrane-bound targets, which enable VSNLs to modulate various cellular signal transduction pathways, including cyclic nucleotide and MAPK signaling. An emerging theme is the direct or indirect effect of VSNLs on gene expression and the interaction with components of membrane trafficking complexes which may determine a role in membrane trafficking of different receptors and ion channels, such as glutamate receptors of the kainate and AMPA subtype, nicotinic ACh receptors and Ca2+-channels. One hypothesis is that the highly homologous VSNLs have evolved to fulfill specialized functions in membrane trafficking and thereby affect neuronal signaling and differentiation in defined subsets of neurons. VSNLs are involved in differentiation processes showing a tumor invasion suppressor function in peripheral organs. Finally, VSNLs play neuroprotective and neurotoxic roles and have been implicated in neurodegenerative diseases.
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影响因子：
34.7
作者：
Burgoyne, Robert D.
通讯作者：
Burgoyne, Robert D.
DOI：
10.1016/j.bbrc.2007.12.153
发表时间：
2008-03-07
影响因子：
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DOI：
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期刊：
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通讯作者：
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影响因子：
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