Salmonella chronic carriage: epidemiology, diagnosis, and gallbladder persistence.

Salmonella chronic carriage: epidemiology, diagnosis, and gallbladder persistence.
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DOI:
10.1016/j.tim.2014.06.007
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发表时间:
2014-11
影响因子:
15.9
通讯作者:
Ryan, Edward T.
Ryan, Edward T.
中科院分区:
生物学1区
文献类型:
--
作者:
Gunn, John S.;Marshall, Joanna M.;Baker, Stephen;Dongol, Sabina;Charles, Richelle C.;Ryan, Edward T.

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伤寒(肠热病)仍然是全世界发病和死亡的主要原因,每年造成超过 2100 万新感染,其中大多数死亡发生在幼儿中。由于引起伤寒的沙门氏菌没有已知的环境储存库,因此慢性、无症状的携带者状态被认为是该细菌在人群中持续存在的一个关键特征。尽管这种疾病对公共卫生很重要,但我们对催化携带的分子机制的理解,以及我们可靠地识别和治疗沙门氏菌携带状态的能力,直到最近才开始取得进展。
Typhoid (enteric fever) remains a major cause of morbidity and mortality worldwide, causing over 21 million new infections annually, with the majority of deaths occurring in young children. As typhoid fever-causing Salmonella have no known environmental reservoir, the chronic, asymptomatic carrier state is thought to be a key feature of continued maintenance of the bacterium within human populations. In spite of the importance of this disease to public health, our understanding of the molecular mechanisms that catalyze carriage, as well as our ability to reliably identify and treat the Salmonella carrier state, have only recently begun to advance.
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