Chronic and acute infection of the gall bladder by Salmonella Typhi: understanding the carrier state.

Chronic and acute infection of the gall bladder by Salmonella Typhi: understanding the carrier state.
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DOI:
10.1038/nrmicro2490
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发表时间:
2011-01
期刊:
Nature reviews. Microbiology
影响因子:
--
通讯作者:
--
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其他
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尽管作出了重大的治疗和预防努力,但全世界每年仍发生数百万新的伤寒感染病例。对于一部分感染者,肠沙门氏菌亚种。伤寒肠杆菌在胆汁中定居,在症状消退后很长一段时间内仍在那里,为疾病的进一步传播提供了一个蓄水池。在这篇进展文章中,我们探讨了我们在理解沙门氏菌的机制方面的最新进展。-主要是伤寒沙门氏菌--在人的胆汁中定居并持续存在。
Despite major treatment and prevention efforts, millions of new typhoid infections occur worldwide each year. For a subset of infected individuals, Salmonella enterica subsp. enterica serovar Typhi colonizes the gall bladder and remains there long after symptoms subside, serving as a reservoir for the further spread of the disease. In this Progress article, we explore recent advances in our understanding of the mechanisms by which Salmonella spp. — predominantly S. Typhi — colonize and persist in the human gall bladder.
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