Prenatal exposure to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) and maternally reported developmental milestones in infancy.
Prenatal exposure to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) and maternally reported developmental milestones in infancy.
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DOI：
10.1289/ehp.11277
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发表时间：
2008-10
影响因子：
10.4
通讯作者：
Olsen J
中科院分区：
文献类型：
--
作者：
Fei C;McLaughlin JK;Lipworth L;Olsen J
全氟辛烷磺酸(PFOS)和全氟辛酸(PFOA)是低浓度存在于普通人群中的含氟有机化合物。动物研究表明，它们可能会在高浓度下影响神经肌肉的发育。我们调查了孕妇血浆全氟辛烷磺酸和全氟辛烷磺酸水平与其子女的运动和智力发育里程碑之间的关系。我们从丹麦国家出生队列中随机选择了1400对孕妇和她们的孩子。对妊娠早期采集的母血样本进行全氟辛烷磺酸和全氟辛酸测定。阿普加评分摘自丹麦国家医院出院登记簿。母亲们在孩子大约6个月和18个月大的时候，使用高度结构化的问卷报告了发育里程碑。全氟辛烷磺酸和全氟辛烷磺酸水平较高的母亲所生的孩子具有类似的阿普加评分，并且几乎与接触水平较低的母亲所生的孩子同时达到所有发育里程碑。全氟辛烷磺酸水平较高的母亲所生的孩子更有可能在较晚的时候开始在没有支持的情况下坐着。我们发现儿童早期的发育里程碑与怀孕早期母体血浆中的全氟辛烷磺酸或全氟辛烷磺酸水平之间没有令人信服的联系。
Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) are fluorinated organic compounds present in the general population at low concentrations. Animal studies have shown that they may affect neuromuscular development at high concentrations. We investigated the association between plasma levels of PFOS and PFOA in pregnant women and motor and mental developmental milestones of their children. We randomly selected 1,400 pairs of pregnant women and their children from the Danish National Birth Cohort. PFOS and PFOA were measured in maternal blood samples taken in early pregnancy. Apgar score was abstracted from the National Hospital Discharge Register in Denmark. Developmental milestones were reported by mothers using highly structured questionnaires when the children were around 6 months and 18 months of age. Mothers who had higher levels of PFOA and PFOS gave birth to children who had similar Apgar scores and reached virtually all of the development milestones at the same time as children born to mothers with lower exposure levels. Children who were born to mothers with higher PFOS levels were slightly more likely to start sitting without support at a later age. We found no convincing associations between developmental milestones in early childhood and levels of PFOA or PFOS as measured in maternal plasma early in pregnancy.
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影响因子：
10.4
作者：
Kärrman A;Ericson I;van Bavel B;Darnerud PO;Aune M;Glynn A;Lignell S;Lindström G
通讯作者：
Lindström G
影响因子：
5
作者：
Fei, Chunyuan;McLaughlin, Joseph K.;Olsen, Jorn
通讯作者：
Olsen, Jorn
影响因子：
4.5
作者：
Luebker, DJ;Case, MT;Butenhoff, JL
通讯作者：
Butenhoff, JL
影响因子：
3.8
作者：
Thibodeaux, JR;Hanson, RG;Lau, C
通讯作者：
Lau, C
影响因子：
4.5
作者：
Luebker, DJ;York, RG;Butenhoff, JL
通讯作者：
Butenhoff, JL