A bone to pick-cellular and molecular mechanisms of bone pain in sickle cell disease.
A bone to pick-cellular and molecular mechanisms of bone pain in sickle cell disease.
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DOI：
10.3389/fpain.2023.1302014
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发表时间：
2023
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影响因子：
--
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中科院分区：
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骨骼是镰状细胞病(SCD)最常见的受累器官之一。骨骼内反复的缺血、氧化应激和炎症在很大程度上是导致骨痛的原因。随着越来越多的SCD患者存活到成年，他们可能会经历衰老和SCD对他们骨骼健康的协同影响。随着骨骼健康的恶化，骨骼疼痛可能会加剧。最近的机械学和观察性研究强调了骨重建和周围神经系统之间的复杂关系。在病理条件下，异常的骨改建在骨痛的传播中起着关键作用。在这篇综述中，我们首先总结了SCD中部分骨并发症的机制和负担。然后，我们讨论了在SCD和非镰状细胞动物模型中描述的导致病理性骨痛的过程。在设计新的治疗方法时，我们强调骨-神经系统相互作用的作用和缺陷，特别是针对镰状细胞群体。最后，我们还讨论了未来的基础和转化性研究，以解决关于应激性红细胞生成和炎症在SCD骨并发症发展中的复杂作用的问题，这可能导致有希望的治疗并减少这一脆弱人群的发病率。
The bone is one of the most commonly affected organs in sickle cell disease (SCD). Repeated ischemia, oxidative stress and inflammation within the bone is largely responsible for promoting bone pain. As more individuals with SCD survive into adulthood, they are likely to experience a synergistic impact of both aging and SCD on their bone health. As bone health deteriorates, bone pain will likely exacerbate. Recent mechanistic and observational studies emphasize an intricate relationship between bone remodeling and the peripheral nervous system. Under pathological conditions, abnormal bone remodeling plays a key role in the propagation of bone pain. In this review, we first summarize mechanisms and burden of select bone complications in SCD. We then discuss processes that contribute to pathological bone pain that have been described in both SCD as well as non-sickle cell animal models. We emphasize the role of bone-nervous system interactions and pitfalls when designing new therapies especially for the sickle cell population. Lastly, we also discuss future basic and translational research in addressing questions about the complex role of stress erythropoiesis and inflammation in the development of SCD bone complications, which may lead to promising therapies and reduce morbidity in this vulnerable population.
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影响因子：
3.3
作者：
Castañeda-Corral G;Jimenez-Andrade JM;Bloom AP;Taylor RN;Mantyh WG;Kaczmarska MJ;Ghilardi JR;Mantyh PW
通讯作者：
Mantyh PW
影响因子：
9
作者：
通讯作者：
--
影响因子：
2.4
作者：
Aguilar, C;Vichinsky, E;Neumayr, L
通讯作者：
Neumayr, L
影响因子：
7.5
作者：
Adesina, Oyebimpe;Brunson, Ann;Wun, Ted
通讯作者：
Wun, Ted
影响因子：
4.1
作者：
Arlet, Jean-Benoit;Courbebaisse, Marie;Ribeil, Jean-Antoine
通讯作者：
Ribeil, Jean-Antoine