Frequency dependent emotion differentiation and directional coupling in amygdala, orbitofrontal and medial prefrontal cortex network with intracranial recordings.
Frequency dependent emotion differentiation and directional coupling in amygdala, orbitofrontal and medial prefrontal cortex network with intracranial recordings.
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DOI：
10.1038/s41380-022-01883-2
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发表时间：
2023-04
影响因子：
11
通讯作者：
Voon, Valerie
中科院分区：
文献类型：
--
作者：
Sonkusare, Saurabh;Qiong, Ding;Zhao, Yijie;Liu, Wei;Yang, Ruoqi;Mandali, Alekhya;Manssuer, Luis;Zhang, Chencheng;Cao, Chunyan;Sun, Bomin;Zhan, Shikun;Voon, Valerie
杏仁核、眶额皮层和内侧前额叶皮层是情绪回路的重要组成部分，但它们的情绪诱发反应和相互作用的直接颅内记录研究较少。这种高保真信号可以揭示精确的光谱动态和价处理中的频率差异，从而对神经调节产生新的见解。在这里，利用独特的时空优势，颅内脑电图（iEEG）从一个队列的35例难治性癫痫患者（71个接触杏仁核，31个OFC和43个mPFC），我们评估的频谱动力学和杏仁核，OFC和mPFC之间的相互作用在情绪图片观看任务。任务诱发的活动表现出更大的宽带γ活动在负条件下相比，在所有三个区域的正条件。同样，在负性条件下，杏仁核和眶额皮层的β活性增加，而mPFC则减少。此外，杏仁核的β活性与效价等级呈显著负相关。关键的是，基于模型的计算分析显示，单向连接从mPFC的杏仁核和OFC-杏仁核和OFC-mPFC之间的双向通信。我们的研究结果提供了直接的神经生理学证据的mPFC的自上而下的影响杏仁核和OFC和杏仁核之间的双向影响，一个多假设的模型。总而言之，在一个相对较大的样本量与人类颅内神经元的记录，我们强调的杏仁核-mPFC-OFC网络的潜在的有针对性的神经调节情绪处理的影响的价依赖性的光谱动力学和二进耦合。
The amygdala, orbitofrontal cortex (OFC) and medial prefrontal cortex (mPFC) form a crucial part of the emotion circuit, yet their emotion induced responses and interactions have been poorly investigated with direct intracranial recordings. Such high-fidelity signals can uncover precise spectral dynamics and frequency differences in valence processing allowing novel insights on neuromodulation. Here, leveraging the unique spatio-temporal advantages of intracranial electroencephalography (iEEG) from a cohort of 35 patients with intractable epilepsy (with 71 contacts in amygdala, 31 in OFC and 43 in mPFC), we assessed the spectral dynamics and interactions between the amygdala, OFC and mPFC during an emotional picture viewing task. Task induced activity showed greater broadband gamma activity in the negative condition compared to positive condition in all the three regions. Similarly, beta activity was increased in the negative condition in the amygdala and OFC while decreased in mPFC. Furthermore, beta activity of amygdala showed significant negative association with valence ratings. Critically, model-based computational analyses revealed unidirectional connectivity from mPFC to the amygdala and bidirectional communication between OFC-amygdala and OFC-mPFC. Our findings provide direct neurophysiological evidence for a much-posited model of top-down influence of mPFC over amygdala and a bidirectional influence between OFC and the amygdala. Altogether, in a relatively large sample size with human intracranial neuronal recordings, we highlight valence-dependent spectral dynamics and dyadic coupling within the amygdala-mPFC-OFC network with implications for potential targeted neuromodulation in emotion processing.
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影响因子：
19.9
作者：
Etkin, Amit;Egner, Tobias;Kalisch, Raffael
通讯作者：
Kalisch, Raffael
影响因子：
5.7
作者：
Friston KJ;Bastos A;Litvak V;Stephan KE;Fries P;Moran RJ
通讯作者：
Moran RJ
影响因子：
4.2
作者：
Anders, Silke;Eippert, Falk;Veit, Ralf
通讯作者：
Veit, Ralf
DOI：
10.1098/rstb.2005.1622
发表时间：
2005-04-29
影响因子：
6.3
作者：
Friston, KJ
通讯作者：
Friston, KJ
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T