Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1.
Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1.
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DOI：
10.1038/nn.3920
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发表时间：
2015-02
影响因子：
25
通讯作者：
Bear, Mark F.
中科院分区：
文献类型：
--
作者：
Cooke, Sam F.;Komorowski, Robert W.;Kaplan, Eitan S.;Gavornik, Jeffrey P.;Bear, Mark F.
Familiarity with stimuli that bring neither reward nor punishment, manifested through behavioural habituation, enables organisms to detect novelty and devote cognition to important elements of the environment. Here we describe in mice a form of long-term behavioural habituation to visual grating stimuli that is selective for stimulus orientation. Orientation-selective habituation (OSH) can be observed both in exploratory behaviour in an open arena, and in a stereotyped motor response to visual stimuli in head-restrained mice. We show that the latter behavioural response, termed a vidget, requires V1. Parallel electrophysiological recordings in V1 reveal that plasticity, in the form of stimulus-selective response potentiation (SRP), occurs in layer 4 of V1 as OSH develops. Local manipulations of V1 that prevent and reverse electrophysiological modifications likewise prevent and reverse memory demonstrated behaviourally. These findings suggest that a form of long-term visual recognition memory is stored via synaptic plasticity in primary sensory cortex.
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影响因子：
5.3
作者：
Andermann ML;Kerlin AM;Reid RC
通讯作者：
Reid RC
影响因子：
64.8
作者：
HORN, G
通讯作者：
HORN, G
影响因子：
2.5
作者：
Histed, Mark H.;Carvalho, Lauren A.;Maunsell, John H. R.
通讯作者：
Maunsell, John H. R.
影响因子：
1.8
作者：
Porciatti, V;Pizzorusso, T;Maffei, L
通讯作者：
Maffei, L
DOI：
10.1126/science.1236425
发表时间：
2013-06-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Constantinople CM;Bruno RM
通讯作者：
Bruno RM