Extracellular Vesicle-Associated RNA as a Carrier of Epigenetic Information.
Extracellular Vesicle-Associated RNA as a Carrier of Epigenetic Information.
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DOI：
10.3390/genes8100240
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发表时间：
2017-09-22
期刊：
影响因子：
3.5
通讯作者：
Di Liegro I
中科院分区：
文献类型：
--
作者：
Di Liegro CM;Schiera G;Di Liegro I
信使RNA（mRNA）代谢和亚细胞定位的转录后调节在发育和细胞分化期间都是极其重要的。除了携带遗传信息外，mRNA还含有顺式作用信号（邮政编码），通常存在于其5′和3′非翻译区（UTR）中。通过结合这些信号，反式作用因子，如RNA结合蛋白（RBP）和/或非编码RNA（ncRNA），控制mRNA的定位，翻译和稳定性。RBP还可以与不同大小的非编码RNA形成复合物。细胞外囊泡（EV）的释放是一个保守的过程，允许正常细胞和癌细胞水平转移分子，从而将特性转移到相邻细胞。通过与特异性分选为EV的蛋白质相互作用，mRNA以及ncRNA可以从细胞转移到细胞。在这篇综述中，我们讨论了不同类型的分子的EV的分选的机制，以及细胞外RNA和相关蛋白在改变受体细胞中的基因表达中的作用。重要的是，一方面，如果RBP在通过EV转移RNA中起关键作用，另一方面，RNA本身可以作为转移蛋白质的载体（即，染色质修饰剂和转录因子），一旦转移，可以改变细胞的表观基因组。
Post-transcriptional regulation of messenger RNA (mRNA) metabolism and subcellular localization is of the utmost importance both during development and in cell differentiation. Besides carrying genetic information, mRNAs contain cis-acting signals (zip codes), usually present in their 5′- and 3′-untranslated regions (UTRs). By binding to these signals, trans-acting factors, such as RNA-binding proteins (RBPs), and/or non-coding RNAs (ncRNAs), control mRNA localization, translation and stability. RBPs can also form complexes with non-coding RNAs of different sizes. The release of extracellular vesicles (EVs) is a conserved process that allows both normal and cancer cells to horizontally transfer molecules, and hence properties, to neighboring cells. By interacting with proteins that are specifically sorted to EVs, mRNAs as well as ncRNAs can be transferred from cell to cell. In this review, we discuss the mechanisms underlying the sorting to EVs of different classes of molecules, as well as the role of extracellular RNAs and the associated proteins in altering gene expression in the recipient cells. Importantly, if, on the one hand, RBPs play a critical role in transferring RNAs through EVs, RNA itself could, on the other hand, function as a carrier to transfer proteins (i.e., chromatin modifiers, and transcription factors) that, once transferred, can alter the cell’s epigenome.
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影响因子：
4.4
作者：
Batagov AO;Kuznetsov VA;Kurochkin IV
通讯作者：
Kurochkin IV
影响因子：
64.5
作者：
Chang CH;Curtis JD;Maggi LB Jr;Faubert B;Villarino AV;O'Sullivan D;Huang SC;van der Windt GJ;Blagih J;Qiu J;Weber JD;Pearce EJ;Jones RG;Pearce EL
通讯作者：
Pearce EL
DOI：
10.1038/mtna.2011.2
发表时间：
2012-02-07
期刊：
Molecular therapy. Nucleic acids
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.6
作者：
Bachmayr-Heyda A;Reiner AT;Auer K;Sukhbaatar N;Aust S;Bachleitner-Hofmann T;Mesteri I;Grunt TW;Zeillinger R;Pils D
通讯作者：
Pils D
影响因子：
4.6
作者：
Abe N;Matsumoto K;Nishihara M;Nakano Y;Shibata A;Maruyama H;Shuto S;Matsuda A;Yoshida M;Ito Y;Abe H
通讯作者：
Abe H