Effect of neonatal hyperoxia followed by concentrated ambient ultrafine particle exposure on cumulative learning in C57Bl/6J mice.
Effect of neonatal hyperoxia followed by concentrated ambient ultrafine particle exposure on cumulative learning in C57Bl/6J mice.
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DOI：
10.1016/j.neuro.2018.06.006
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发表时间：
2018-07
期刊：
影响因子：
3.4
通讯作者：
Cory-Slechta DA
中科院分区：
文献类型：
--
作者：
Morris-Schaffer K;Sobolewski M;Allen JL;Marvin E;Yee M;Arora M;O'Reilly MA;Cory-Slechta DA
Hyperoxia during treatment for prematurity may enhance susceptibility to other risk factors for adverse brain development, such as air pollution exposure, as both of these risk factors have been linked to a variety of adverse neurodevelopmental outcomes. This study investigated the combined effects of neonatal hyperoxia followed by inhalation of concentrated ambient ultrafine particles (CAPS, <100nm in aerodynamic diameter) on learning. C57BL/6J mice were birthed into 60% oxygen until postnatal day (PND) 4 and subsequently exposed to filtered air or to CAPS using the Harvard University Concentrated Ambient Particle System (HUCAPS) from PND 4–7 and 10–13. Behavior was assessed on a fixed interval (FI) schedule of reinforcement in which reward is available only after a fixed interval of time elapses, as well as expected reductions in behavior during an extinction procedure when reward was withheld. Both produce highly comparable behavioral performance across species. Performance measures included rate of responding, response accuracy, and temporal control (quarter life). Exposure to hyperoxia or CAPS resulted in lower mean quarter life values, an effect that was further enhanced in males by combined exposure, findings consistent with delayed learning of the FI schedule. Females also initially exhibited greater reductions in quarter life values following the combined exposure to hyperoxia and CAPS and delayed reductions in response rates during extinction. Combined hyperoxia and CAPS produced greater learning deficits than either risk factor alone, consistent with enhanced neurodevelopmental toxicity, findings that could reflect a convergence of both insults on common neurobiological systems. The basis for sex differences in outcome warrants further research. This study highlights the potential for heightened risk of adverse neurodevelopment outcomes in individuals born preterm in regions with higher levels of ultrafine particle (UFP) air pollution, in accord with the multiplicity of risk factors extant in the human environment.
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DOI：
10.1016/s0140-6736(17)30505-6
发表时间：
2017-05-13
期刊：
Lancet (London, England)
影响因子：
--
作者：
Cohen AJ;Brauer M;Burnett R;Anderson HR;Frostad J;Estep K;Balakrishnan K;Brunekreef B;Dandona L;Dandona R;Feigin V;Freedman G;Hubbell B;Jobling A;Kan H;Knibbs L;Liu Y;Martin R;Morawska L;Pope CA 3rd;Shin H;Straif K;Shaddick G;Thomas M;van Dingenen R;van Donkelaar A;Vos T;Murray CJL;Forouzanfar MH
通讯作者：
Forouzanfar MH
影响因子：
10.4
作者：
Allen JL;Conrad K;Oberdörster G;Johnston CJ;Sleezer B;Cory-Slechta DA
通讯作者：
Cory-Slechta DA
影响因子：
10.4
作者：
Basagaña X;Esnaola M;Rivas I;Amato F;Alvarez-Pedrerol M;Forns J;López-Vicente M;Pujol J;Nieuwenhuijsen M;Querol X;Sunyer J
通讯作者：
Sunyer J
影响因子：
3.5
作者：
Arnold AP
通讯作者：
Arnold AP
影响因子：
3.7
作者：
Brannon, Elizabeth M.;Suanda, Sumarga;Libertus, Klaus
通讯作者：
Libertus, Klaus