Astragalus membranaceus-Polysaccharides Ameliorates Obesity, Hepatic Steatosis, Neuroinflammation and Cognition Impairment without Affecting Amyloid Deposition in Metabolically Stressed APPswe/PS1dE9 Mice.
Astragalus membranaceus-Polysaccharides Ameliorates Obesity, Hepatic Steatosis, Neuroinflammation and Cognition Impairment without Affecting Amyloid Deposition in Metabolically Stressed APPswe/PS1dE9 Mice.
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DOI：
10.3390/ijms18122746
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发表时间：
2017-12-18
影响因子：
5.6
通讯作者：
Shiao YJ
中科院分区：
文献类型：
--
作者：
Huang YC;Tsay HJ;Lu MK;Lin CH;Yeh CW;Liu HK;Shiao YJ
黄芪是常用的中药，用于加强宿主的防御系统。黄芪多糖是黄芪的有效成分，具有免疫调节、抗氧化、抗糖尿病、抗炎和神经保护等多种重要生物活性。在本研究中，我们确定了黄芪多糖对代谢应激转基因小鼠的影响，以开发这种大分子用于治疗散发性阿尔茨海默病，一种具有代谢危险因素的神经退行性疾病。在老年斑出现之前的10周龄，对转基因小鼠进行高脂饮食和低剂量链脲佐菌素注射的组合处理，以建立代谢应激小鼠模型。从14周开始给予黄芪多糖，共7周。我们发现，黄芪多糖减少代谢应激引起的体重增加，胰岛素和胰岛素和瘦素水平，胰岛素抵抗和肝脏甘油三酯。黄芪多糖还改善代谢应激加重的口服葡萄糖不耐受，虽然空腹血糖只是暂时降低。在大脑中，代谢应激引起的星形胶质细胞增生和斑块附近的小胶质细胞活化也减少了黄芪多糖管理。然而，黄芪多糖给药对斑块沉积没有显著影响。这些结果表明，黄芪多糖可用于改善代谢应激诱导的糖尿病和随后的神经炎症，从而改善代谢应激转基因小鼠的行为表现。
Astragalus membranaceus is commonly used in traditional Chinese medicine for strengthening the host defense system. Astragalus membranaceus-polysaccharides is an effective component with various important bioactivities, such as immunomodulation, antioxidant, anti-diabetes, anti-inflammation and neuroprotection. In the present study, we determine the effects of Astragalus membranaceus-polysaccharides on metabolically stressed transgenic mice in order to develop this macromolecules for treatment of sporadic Alzheimer’s disease, a neurodegenerative disease with metabolic risk factors. Transgenic mice, at 10 weeks old prior to the appearance of senile plaques, were treated in combination of administrating high-fat diet and injecting low-dose streptozotocin to create the metabolically stressed mice model. Astragalus membranaceus-polysaccharides was administrated starting at 14 weeks for 7 weeks. We found that Astragalus membranaceus-polysaccharides reduced metabolic stress-induced increase of body weight, insulin and insulin and leptin level, insulin resistance, and hepatic triglyceride. Astragalus membranaceus-polysaccharides also ameliorated metabolic stress-exacerbated oral glucose intolerance, although the fasting blood glucose was only temporally reduced. In brain, metabolic stress-elicited astrogliosis and microglia activation in the vicinity of plaques was also diminished by Astragalus membranaceus-polysaccharides administration. The plaque deposition, however, was not significantly affected by Astragalus membranaceus-polysaccharides administration. These findings suggest that Astragalus membranaceus-polysaccharides may be used to ameliorate metabolic stress-induced diabesity and the subsequent neuroinflammation, which improved the behavior performance in metabolically stressed transgenic mice.
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影响因子：
2.7
作者：
Liu H;Bai J;Weng X;Wang T;Li M
通讯作者：
Li M
影响因子：
5.6
作者：
de la Monte, Suzanne M.
通讯作者：
de la Monte, Suzanne M.
DOI：
10.1073/pnas.97.13.7609
发表时间：
2000-06-20
影响因子：
11.1
作者：
Skovronsky, DM;Zhang, B;Lee, VMY
通讯作者：
Lee, VMY
DOI：
10.1016/j.jamcollsurg.2011.12.016
发表时间：
2012-04-01
影响因子：
5.2
作者：
Matheson, Paul J.;Franklin, Glen A.;Garrison, Richard N.
通讯作者：
Garrison, Richard N.
影响因子：
2.7
作者：
Liu, Li;Chen, Shibiao;Mo, Fei
通讯作者：
Mo, Fei