Effectiveness of Electroconvulsive Therapy in Patients With Advanced Parkinson Disease
Effectiveness of Electroconvulsive Therapy in Patients With Advanced Parkinson Disease
复制标题
电休克治疗晚期帕金森病患者的有效性
DOI：
10.1097/yct.0000000000000732
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Kawanishi Chiaki
中科院分区：
文献类型：
--
作者：
Murayama Tomonori;Kobayashi Seiju;Matsuoka Takeshi;Kigawa Yoshiyasu;Ishida Tomotaka;Hyakumachi Kengo;Utsumi Kumiko;Kawanishi Chiaki
目的除了运动症状外，帕金森病（PD）患者还患有各种精神合并症，包括冲动控制障碍（ICD）。此外，抗帕金森病药物有时会引起精神症状。抗帕金森病药物和抗精神病药物在药效学上存在竞争，精神药物，包括抗抑郁药，可能会加重运动症状或诱发不良反应。考虑到这种相互矛盾的情况下，我们研究了电休克治疗（ECT）对运动和精神症状在PD.MethodsWe回顾性研究了12个PD患者的先进的运动症状和耐药的精神症状，包括ICD，谁经历了ECT的有效性。在ECT治疗前后，PD运动症状的严重程度采用Hoehn和Yahr分期进行评估，而精神症状则采用神经精神量表进行评估。患者的抗帕金森病药物和抗精神病药物的剂量也进行了评估之前和之后ECT.ResultsMean Hoehn和Yahr和神经精神量表评分后ECT显着下降。ECT后5例患者ICD症状消失。运动症状和精神症状改善持续时间超过1年的分别为5例和9例。此外，每日剂量的抗帕金森病药物显着减少6 cases.ConclusionsOur结果表明，ECT是有效的严重的运动症状和精神症状的晚期PD患者。ECT可能是一个解决冲突的问题，同时治疗运动和精神症状的PD。
ObjectivesIn addition to motor symptoms, patients with Parkinson disease (PD) experience various psychiatric comorbidities, including impulse control disorders (ICDs). Moreover, antiparkinsonian drugs sometimes cause psychiatric symptoms. Antiparkinsonian and antipsychotic drugs are competitive in pharmacodynamics, and psychotropic drugs, including antidepressants, may worsen motor symptoms or induce adverse reactions. Considering this conflicting situation, we examined the effectiveness of electroconvulsive therapy (ECT) on both motor and psychiatric symptoms in PD.MethodsWe retrospectively examined 12 PD patients with advanced motor symptoms and drug-resistant psychiatric symptoms, including ICDs, who had undergone ECT. Both before and after ECT, the severity of PD motor symptoms were evaluated using Hoehn and Yahr staging, while psychiatric symptoms were evaluated using the Neuropsychiatric Inventory. The patients' doses of antiparkinsonian and antipsychotic drugs were also assessed before and after ECT.ResultsBoth the mean Hoehn and Yahr and Neuropsychiatric Inventory scores were significantly decreased after ECT. The symptoms of ICDs, which were observed in 5 patients, disappeared following ECT. Improvements in motor symptoms and psychiatric symptoms lasted for more than 1 year in 5 cases and 9 cases, respectively. Furthermore, the daily dose of antiparkinsonian drugs was significantly decreased in 6 cases.ConclusionsOur results demonstrated that ECT was effective for both severe motor symptoms and psychiatric symptoms in advanced PD patients. ECT might be a solution for the conflicting problem of treating both motor and psychiatric symptoms in PD.
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ECT 诱发帕金森病抑郁症患者的谵妄。
DOI：
10.1176/jnp.3.4.405
发表时间：
1991
期刊：
The Journal of neuropsychiatry and clinical neurosciences
影响因子：
--
作者：
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The American journal of psychiatry
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具有断断续续症状的帕金森病患者电休克治疗后改善的预测因素
影响因子：
3.3
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以癫痫病灶体积表示的电惊厥治疗刺激剂量
DOI：
10.1097/00124509-200603000-00012
发表时间：
2006
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The Journal of ECT
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DOI：
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发表时间：
1997
期刊：
Convulsive Therapy
影响因子：
--
作者：
D. Aarsland;Larsen Jp;O. Waage;Langeveld Jh
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