Functional Connectivity Decreases with Metabolic Stress in Sickle Cell Disease.
Functional Connectivity Decreases with Metabolic Stress in Sickle Cell Disease.
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DOI：
10.1002/ana.25891
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发表时间：
2020-11
影响因子：
11.2
通讯作者：
Lee JM
中科院分区：
文献类型：
--
作者：
Fields ME;Mirro AE;Guilliams KP;Binkley MM;Gil Diaz L;Tan J;Fellah S;Eldeniz C;Chen Y;Ford AL;Shimony JS;King AA;An H;Smyser CD;Lee JM
患有镰状细胞病的儿童即使未受中风影响也会出现认知缺陷。使用功能连接MRI作为认知功能的潜在生物标志物，我们测试了我们的假设，即镰状细胞病儿童的功能连接性降低，并且经历最大代谢应激的儿童（由氧提取分数升高表示）的连接性最低。我们前瞻性地获得了健康对照组和镰状细胞病儿童的脑MRI和认知测试。我们分析了60名参与者的数据（20名对照，40名镰状细胞病）。两个队列之间的整体认知或认知子域没有差异。然而，我们发现与对照组相比，镰状细胞病患者的感觉运动、横向感觉运动、听觉、显着性和皮层下网络的功能连接减少。此外，随着白色物质氧提取分数的增加，视觉内的连通性增加。（p = 0.008，参数估计值[95% CI] = −0.760 [−1.297，−0.224]），默认模式（p = 0.012，参数估计值[95%CI] =-0.417 [-0.731，-0.104]），扣带-盖（p = 0.009，参数估计值[95%CI] =-0.883 [-1.517，-0.250]）网络减少。我们的结论是，与对照组相比，镰状细胞病儿童的这些解剖学上连续的网络中的功能连接性减弱，即使在认知测试中没有发现差异。增加的白色物质氧提取分数与选择网络中的连接性降低相关。这些数据表明，氧提取分数升高和功能连接中断是镰状细胞病认知功能下降的潜在症状前神经影像学生物标志物。
Children with sickle cell disease experience cognitive deficits even when unaffected by stroke. Using functional connectivity MRI as a potential biomarker of cognitive function, we tested our hypothesis that children with sickle cell disease would have decreased functional connectivity, and that children experiencing the greatest metabolic stress, indicated by elevated oxygen extraction fraction, would have the lowest connectivity. We prospectively obtained brain MRIs and cognitive testing in healthy controls and children with sickle cell disease. We analyzed data from 60 participants (20 controls, 40 sickle cell disease). There was no difference in global cognition or cognitive subdomains between cohorts. However, we found decreased functional connectivity within the sensory-motor, lateral sensory-motor, auditory, salience and subcortical networks in participants with sickle cell disease compared to controls. Further, as white matter oxygen extraction fraction increased, connectivity within the visual (p = 0.008, parameter estimate [95% CI] = −0.760 [−1.297, −0.224]), default mode (p = 0.012, parameter estimate [95% CI] = −0.417 [−0.731, −0.104]), and cingulo-opercular (p = 0.009, parameter estimate [95% CI] = −0.883 [−1.517, −0.250]) networks decreased. We conclude that there is diminished functional connectivity within these anatomically-contiguous networks in children with sickle cell disease compared to controls, even when differences are not seen with cognitive testing. Increased white matter oxygen extraction fraction was associated with decreased connectivity in select networks. These data suggest that elevated oxygen extraction fraction and disrupted functional connectivity are potentially pre-symptomatic neuroimaging biomarkers for cognitive decline in sickle cell disease.
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DOI：
10.1073/pnas.1110024108
发表时间：
2011-11-22
影响因子：
11.1
作者：
Hawellek, David J.;Hipp, Joerg F.;Engel, Andreas K.
通讯作者：
Engel, Andreas K.
影响因子：
3.7
作者：
Colombatti R;Lucchetta M;Montanaro M;Rampazzo P;Ermani M;Talenti G;Baracchini C;Favero A;Basso G;Manara R;Sainati L
通讯作者：
Sainati L
影响因子：
3.2
作者：
Hijmans, Channa T.;Fijnvandraat, Karin;Oosterlaan, Jaap
通讯作者：
Oosterlaan, Jaap
影响因子：
3
作者：
Bazin, Pierre-Louis;Cuzzocreo, Jennifer L.;Pham, Dzung L.
通讯作者：
Pham, Dzung L.
影响因子：
3.3
作者：
Bush AM;Coates TD;Wood JC
通讯作者：
Wood JC