Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer.
Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer.
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结直肠癌患者的血清胰岛素样生长因子（IGF）-II和IGF结合蛋白-2。
DOI：
10.1054/bjoc.2000.1462
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发表时间：
2000-11
影响因子：
8.8
通讯作者：
O'Dwyer ST
中科院分区：
文献类型：
--
作者：
Renehan AG;Jones J;Potten CS;Shalet SM;O'Dwyer ST
本研究探讨了92例大肠癌患者血清胰岛素样生长因子（IGF-I、IGF-II）及其结合蛋白（IGFBP）-2、IGFBP-3水平与临床病理指标的关系。与57名正常结肠镜检查的人（对照组）进行了比较。27例检查到序列改变。由于IGF相关肽具有年龄和性别依赖性，因此将绝对浓度转换为标准差评分（SDS）。与对照组相比，Dukes A（n= 12 P< 0.001）和Dukes B（n= 25 P< 0.001）病例的平均IGF-II SDS升高，但在晚期疾病中没有升高。与对照组相比，Dukes B组（P< 0.001）、Dukes C组（n= 13 P< 0.001）和晚期疾病组（n= 42 P< 0.0001）患者的平均IGFBP-2 SDS显著升高，从早期疾病到晚期疾病有显著趋势（单因素方差分析P< 0.001）。此外，IGFBP-2 SDS与肿瘤大小呈正相关（P= 0.01），并在根治性切除术后显著下降（P= 0.04），表明循环水平反映了肿瘤负荷。我们测试了IGFBP-2 SDS针对三个终点的潜在肿瘤标志物特征：单独转移;单独局部盆腔复发;以及转移和复发的组合。IGFBP-2单药（≥ + 2SD）的敏感性适中，分别为55%、46%和52%，但与CEA联合使用时，分别大幅增加至90%、77%和86%。我们的结论是，血清IGF-II和IGFBP-2的配置文件可能提供深入了解潜在的生物学机制，血清IGFBP-2可能有一个辅助作用，在大肠癌患者的癌症监测。2000癌症研究运动
This study explored the relationships of serum insulin-like growth factors, IGF-I and IGF-II, and their binding proteins (IGFBP)-2 and IGFBP-3, with key clinicopathological parameters in 92 patients with colorectal cancer (cases). Comparisons were made with 57 individuals who had a normal colonoscopy (controls). Serial changes were examined in 27 cases. As IGF-related peptides are age- and sex-dependent, absolute concentrations were converted to standard deviation scores (SDS). Mean IGF-II SDS were elevated in Dukes A (n= 12 P< 0.001) and Dukes B (n= 25 P< 0.001) cases compared with controls, but not in advanced disease. Compared with controls, mean IGFBP-2 SDS were significantly elevated in patients with Dukes B (P< 0.001), Dukes C (n= 13 P< 0.001) and advanced disease (n= 42 P< 0.0001), with a significant trend from early to advanced disease (one-way ANOVA P< 0.001). Furthermore, IGFBP-2 SDS were positively related to tumour size (P= 0.01) and fell significantly in patients following curative resection (P= 0.04), suggesting that circulating levels reflect tumour load. We tested the potential tumour marker characteristics of IGFBP-2 SDS against three endpoints: metastasis alone; local pelvic recurrence alone; and metastasis and recurrence combined. The sensitivities for IGFBP-2 alone (≥ + 2SD) were modest at 55%, 46%, and 52%, but in combination with CEA, increased substantially to 90%, 77% and 86%, respectively. We conclude that the serum IGF-II and IGFBP-2 profiles may provide insights into underlying biological mechanisms, and that serum IGFBP-2 may have an adjunct role in cancer surveillance in patients with colorectal cancer. © 2000 Cancer Research Campaign
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