Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke.
Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke.
复制标题
发育和病理过程中的脑血管生成：中风后神经血管损伤和血管生成恢复。
DOI：
10.1111/j.1742-4658.2009.07176.x
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发表时间：
2009-09
期刊：
影响因子：
--
通讯作者：
Lo EH
中科院分区：
文献类型：
--
作者：
Arai K;Jin G;Navaratna D;Lo EH
脑卒中后的病理生理反应非常复杂。到目前为止，仅仅关注拯救神经元还没有发现任何临床有效的神经保护剂。为了解决这一局限性，开发了神经血管单元的概念。在这个概念框架内，脑功能和功能障碍表现在神经元、神经胶质和血管成分之间的细胞-细胞信号传导水平上。对于中风，神经血管界面的协调反应将介导缺血性和出血性脑组织中的急性和慢性事件。在这篇简短的综述中，我们简要地调查了两个有代表性的中风神经血管反应的例子。在神经血管损伤的早期急性期，血脑屏障扰动应占主导地位，各种基质蛋白酶发挥关键作用。在延迟期，脑血管生成可能为神经元重塑提供关键的神经血管基质。在这篇小综述中，我们提出了这样的假设，即神经血管反应的双相性代表了受损脑实质触发脑血管生成和修复的内源性尝试。这种现象可以允许急性有害信号在中风恢复期间转变为有益效果。了解神经血管信号和底物如何从最初的损伤过渡到血管新生恢复将是重要的，如果我们要找到新的治疗中风的方法。
Pathophysiologic responses in brain after stroke are highly complex. Thus far, a singular focus on saving neurons alone has not revealed any clinically effective neuroprotectants. To address this limitation, the concept of a neurovascular unit was developed. Within this conceptual framework, brain function and dysfunction are manifested at the level of cell–cell signaling between neuronal, glial and vascular elements. For stroke, coordinated responses at the neurovascular interface will mediate acute as well as chronic events in ischemic and hemorrhagic brain tissue. In this minireview, we briefly survey two representative examples of neurovascular responses in stroke. During the early acute phase of neurovascular injury, blood– brain barrier perturbations should predominate with key roles for various matrix proteases. During the delayed phase, brain angiogenesis may provide the critical neurovascular substrates for neuronal remodeling. In this minireview, we propose the hypothesis that the biphasic nature of neuro-vascular responses represents an endogenous attempt by damaged parenchyma to trigger brain angiogenesis and repair. This phenomenon may allow acute deleterious signals to transition into beneficial effects during stroke recovery. Understanding how neurovascular signals and substrates make the transition from initial injury to angiogenic recovery will be important if we are to find new therapeutic approaches for stroke.
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影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
影响因子：
8.3
作者：
KRUPINSKI, J;KALUZA, J;WANG, JM
通讯作者：
WANG, JM
影响因子：
8.3
作者：
CHEN, HH;CHIEN, CH;LIU, HM
通讯作者：
LIU, HM
影响因子：
8.3
作者：
Castellanos, Mar;Sobrino, Tomas;Davalos, Antoni
通讯作者：
Davalos, Antoni
DOI：
10.1111/j.1365-2990.1997.tb01315.x
发表时间：
1997-10-01
影响因子：
5
作者：
Anthony, DC;Ferguson, B;Perry, VH
通讯作者：
Perry, VH