Chemical Exchange Saturation Transfer MRI Signal Loss of the Substantia Nigra as an Imaging Biomarker to Evaluate the Diagnosis and Severity of Parkinson's Disease.
Chemical Exchange Saturation Transfer MRI Signal Loss of the Substantia Nigra as an Imaging Biomarker to Evaluate the Diagnosis and Severity of Parkinson's Disease.
复制标题
化学交换饱和转移 MRI 黑质信号丢失作为成像生物标志物评估帕金森病的诊断和服务
DOI：
10.3389/fnins.2017.00489
复制
发表时间：
2017
影响因子：
4.3
通讯作者：
Zhou J
中科院分区：
文献类型：
--
作者：
Li C;Chen M;Zhao X;Wang R;Chen H;Su W;Li S;Lou B;Song G;Zhang S;Zhang J;Zhou J
帕金森病（PD）的早期诊断和疾病严重程度的准确评估是对PD患者进行干预和治疗的关键。在本研究中，我们应用化学交换饱和转移（CEST）成像在不同阶段的PD患者，探讨黑质CEST信号丢失作为PD的成像生物标志物的临床价值。PD患者黑质CEST信号强度（包括酰胺质子转移加权或APTw、总CEST或CESTtotal）随PD进展呈明显下降趋势。与正常对照组相比，PD患者的APTw和CEST总强度在早期和晚期均显著降低。晚期或晚期PD患者的黑质APTw和CEST总值也显著低于早期PD患者。单侧症状的PD患者患侧黑质APTw和CEST total值显著低于正常对照组。PD患者APTw和CEST总值与疾病严重程度和病程相关。我们的研究结果表明，黑质CEST MRI信号是一个潜在的成像生物标志物，用于诊断和监测PD的严重程度。
The early diagnosis of Parkinson's disease (PD) and the accurate evaluation of disease severity are crucial for intervention and treatment in PD patients. In this study, we applied chemical exchange saturation transfer (CEST) imaging to patients at different stages of PD and explored the clinical value of the CEST signal loss of the substantia nigra as an imaging biomarker of PD. The measured CEST signal intensities (including amide proton transfer-weighted or APTw, and total CEST or CESTtotal) of the substantia nigra in PD patients showed a significantly decreased tendency with PD progression. Compared to normal controls, the APTw and CESTtotal intensities of PD patients significantly decreased at both the early and advanced or late stages. These APTw and CESTtotal values of the substantia nigra were also significantly lower in advanced or late stage PD patients than in early stage PD patients. For PD patients with unilateral symptoms, the APTw and CESTtotal values in the substantia nigra on the affected side were significantly lower than those in normal controls. Both the APTw and CESTtotal values of PD were significantly correlated with the severity of disease and disease duration. Our findings suggest that the CEST MRI signal of the substantia nigra is a potential imaging biomarker for the diagnosis and monitoring of the severity of PD.
登录
查看更多内容
影响因子：
4.8
作者：
Manza P;Zhang S;Li CS;Leung HC
通讯作者：
Leung HC
影响因子：
3.3
作者：
Heo HY;Zhang Y;Jiang S;Lee DH;Zhou J
通讯作者：
Zhou J
影响因子：
2.9
作者：
Tietze, Anna;Blicher, Jakob;Mikkelsen, Irene Klaerke;Ostergaard, Leif;Strother, Megan K.;Smith, Seth A.;Donahue, Manus J.
通讯作者：
Donahue, Manus J.
影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
2.2
作者：
Ward, KM;Aletras, AH;Balaban, RS
通讯作者：
Balaban, RS