Measurement of Cortical Atrophy and Its Correlation to Memory Impairment in Patients With Asymptomatic Carotid Artery Stenosis Based on VBM-DARTEL.
Measurement of Cortical Atrophy and Its Correlation to Memory Impairment in Patients With Asymptomatic Carotid Artery Stenosis Based on VBM-DARTEL.
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基于VBM-DARTEL的无症状颈动脉狭窄患者皮质萎缩测量及其与记忆障碍的相关性
DOI：
10.3389/fnagi.2021.620763
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发表时间：
2021
影响因子：
4.8
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Wang P;Cai H;Luo R;Zhang Z;Zhang D;Zhang Y
目的严重颈动脉狭窄(CAS)可导致灰质(GM)萎缩和记忆障碍，但其潜在机制尚不清楚。因此，我们的目标是在无症状的严重CAS患者中识别记忆障碍和GM萎缩，并探讨它们之间的可能相关性。方法对24例无症状重症CAS患者和10例健康体检者进行简易智能状态检查(MMSE)和临床记忆量表(CMS)检查，并进行7T磁共振成像(MRI)检查。对场强不均匀进行了校正。使用VBM8对图像进行处理，并对GM图像进行翻转。首先，采用Dartel算法对单侧CAS患者的11张翻转图像和10张非翻转图像以及5张翻转图像和5张非翻转图像进行预处理，并进行方差分析(ANOVA)。其次，对单侧患者的翻转和非翻转图像进行类似的预处理，并使用配对t检验进行分析。第三，对24例患者的非翻转GM图像和CMS评分进行多元回归分析。相应地修正了滋扰变量。结果患者与对照组的基本信息匹配良好。MMSE评分均在正常范围，但记忆功能明显下降(均P<；0.05)。前循环区患者的GM体积明显减少。狭窄侧大脑半球萎缩程度较大。左侧盖部、三角部和额中回的GM体积与CMS总分呈显著正相关(r>0.7，P=0.001)。左侧额中回与联想记忆呈显著正相关(r=0.853，P=0.001)。左侧盖部与语义记忆呈中度正相关(r=0.695，P=0.001)。结论无症状CAS患者存在记忆障碍。双侧前循环区广泛萎缩。狭窄侧大脑半球萎缩程度较重。患者的记忆障碍可能与左额回的萎缩有关，不同区域的萎缩可能导致不同的记忆障碍。
Objective Severe carotid artery stenosis (CAS) can lead to atrophy of gray matter (GM) and memory impairment; however, the underlying mechanism is unknown. Thus, we aimed to identify memory impairment and GM atrophy and explore the possible correlation between them in patients with asymptomatic severe CAS. Methods Twenty-four patients with asymptomatic severe CAS and 10 healthy controls completed the mini-mental state examination (MMSE) and clinical memory scale (CMS) and underwent 7T magnetic resonance imaging (MRI) scan. Field intensity inhomogeneities were corrected. Images were processed using VBM8, and GM images were flipped. First, 11 flipped and 10 non-flipped images of patients with unilateral CAS and 5 flipped and 5 non-flipped images of controls were pre-processed using DARTEL algorithm and analyzed using an analysis of variance (ANOVA). Second, flipped and non-flipped images of unilateral patients were similarly pre-processed and analyzed using the paired t-test. Third, pre-processed non-flipped GM images and CMS scores of 24 patients were analyzed by multiple regression analysis. Nuisance variables were corrected accordingly. Results Basic information was well matched between patients and controls. MMSE scores of patients were in the normal range; however, memory function was significantly reduced (all P < 0.05). GM volumes of patients were significantly reduced in the anterior circulation regions. The stenosis-side hemispheres showed greater atrophy. GM volumes of the left pars opercularis, pars triangularis, and middle frontal gyrus were strongly positively correlated with the total scores of CMS (all r > 0.7, P = 0.001). Additionally, the left middle frontal gyrus was strongly positively correlated with associative memory (r = 0.853, P = 0.001). The left pars opercularis was moderately positively correlated with semantic memory (r = 0.695, P = 0.001). Conclusion Patients with asymptomatic CAS suffer from memory impairment. Bilateral anterior circulation regions showed extensive atrophy. The hemisphere with stenosis showed severer atrophy. Memory impairment in patients may be related to atrophy of the left frontal gyrus and atrophy of different regions may result in different memory impairments.
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影响因子：
5.1
作者：
Kim HJ;Ye BS;Yoon CW;Noh Y;Kim GH;Cho H;Jeon S;Lee JM;Kim JH;Seong JK;Kim CH;Choe YS;Lee KH;Kim ST;Kim JS;Park SE;Kim JH;Chin J;Cho J;Kim C;Lee JH;Weiner MW;Na DL;Seo SW
通讯作者：
Seo SW
影响因子：
56.9
作者：
Courtney, SM;Petit, L;Haxby, JV
通讯作者：
Haxby, JV
影响因子：
4.2
作者：
Asllani, Iris;Slattery, Pamelia;Fafard, Alexander;Pavol, Marykay;Lazar, Ronald M.;Marshall, Randolph S.
通讯作者：
Marshall, Randolph S.
影响因子：
14.5
作者：
Konishi, S;Nakajima, K;Miyashita, Y
通讯作者：
Miyashita, Y
影响因子：
2.6
作者：
Casas-Hernanz, Laura;Garolera, Maite;Aguilar, Miquel
通讯作者：
Aguilar, Miquel