B cell progenitors have different growth requirements before and after immunoglobulin heavy chain commitment
B cell progenitors have different growth requirements before and after immunoglobulin heavy chain commitment
复制标题
B 细胞祖细胞在免疫球蛋白重链定型前后具有不同的生长要求
DOI：
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发表时间：
1988
影响因子：
15.3
通讯作者：
Christopher J Paigei
中科院分区：
文献类型：
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作者：
Helmut Sauter;Christopher J Paigei
Using the clonable pre-B cell assay, we have identified B cell progenitors that are not yet committed to the production of a particular H chain allele. These cells represent approximately 10-20% of clonable pre-B cells found in 15-d fetal liver. The clonable pre-B cell assay provides an environment adequate for the expansion and differentiation of these cells into mature, Ig-secreting, cells. Using the same methodology, we have also identified progenitors that are uncommitted to the production of a particular L chain isotype. Moreover, investigating the growth requirements for clonable pre-B cells has led to the discovery of selective growth conditions that distinguish cells before and after commitment to H chain allotype.
鼠免疫球蛋白同种型的单克隆抗体。
影响因子：
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作者：
Weiss,S;Lehmann,K;Cohn,M
通讯作者：
Cohn,M
使用单克隆抗小鼠免疫球蛋白检测小鼠抗体。
影响因子：
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作者：
Yelton,DE;Desaymard,C;Scharff,MD
通讯作者：
Scharff,MD