Learning of new associations invokes a major change in modulations of cortical beta oscillations in human adults
Learning of new associations invokes a major change in modulations of cortical beta oscillations in human adults
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学习新的关联会引起成年人皮质β振荡调节的重大变化
DOI：
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
B. Chernyshev
中科院分区：
文献类型：
--
作者：
A. Pavlova;N. Tyulenev;V. Tretyakova;V.V. Skavronskaya;A. Nikolaeva;A. Prokofyev;T. Stroganova;B. Chernyshev
大规模的皮质β (β)振荡与学习过程有关，但其确切作用仍存在争议。我们探索了β振荡的动力学，而25名成年参与者通过反复试验，学习了四种听觉假词与身体四肢运动之间的新联系。我们使用脑磁图来评估伴随线索触发运动的学习诱导的β调制变化。我们的研究结果表明，随着学习的进行，与运动相关的β振荡的时空特征发生了重大转变。在学习早期，多个皮质区域的β-权力抑制早在运动开始前就出现了，并持续整个行为试验。随着学习进展和任务表现达到渐近线，β抑制被广泛而持久的β权力上升所取代。β-功率上升在正确运动反应开始后不久开始，主要包括左半球前额叶和内侧颞叶区域。在学习的两个阶段（规则熟悉之前和之后），这种决策后β能力预测了每次试验的反应时间（RT），但方式相反。当被试开始习得联想规则并逐渐提高任务绩效时，RT的降低与决策后β频带功率的增加相关。反复正确地执行学习到的规则将这种相关性反过来，更快（更自信）的反应与较弱的决策后β带同步相关。我们的研究结果表明，最大的β活动与学习的不同阶段有关，并可能有助于加强分布式记忆网络中新学到的关联。
Large-scale cortical beta (β) oscillations have been implicated in the learning processes but their exact role is debated. We explored the dynamics of β-oscillations while 25 adult participants learned, through trial and error, novel associations between four auditory pseudowords and movements of four body extremities. We used MEG to evaluate learninginduced changes in beta modulation accompanying cue-triggered movements. Our findings showed that spatial-temporal characteristics of movement-related β-oscillations underwent a major transition as learning proceeded. Early in learning, suppression of β-power in multiple cortical areas occurred long before movement initiation and sustained throughout the whole behavioral trial. As learning advanced and task performance reached asymptote, βsuppression was replaced by a widespread and prolonged rise in β-power. The β-power rise started shortly after the initiation of correct motor response and mainly comprised the prefrontal and medial temporal regions of the left hemisphere. This post-decision β-power predicted trial-by-trial response times (RT) at both stages of learning (before and after the rules become familiar) but in opposite ways. When a subject started to acquire associative rules and gradually improved task performance, a decrease in RT was correlated with the increase in the post-decision β-band power. Repeatedly correct implementation of the learned rules reversed this correlation in the opposite direction with faster (more confident) responses associated with the weaker post-decision β-band synchronization. Our findings suggest that maximal beta activity is pertinent to a distinct stage of learning and may serve to strengthen the newly learned association in a distributed memory network.
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DOI：
10.1073/pnas.0308538101
发表时间：
2004-06-29
影响因子：
11.1
作者：
Brovelli, A;Ding, MZ;Bressler, SL
通讯作者：
Bressler, SL
DOI：
10.1073/pnas.0404965101
发表时间：
2004-09-07
影响因子：
11.1
作者：
Gallistel, CR;Fairhurst, S;Balsam, P
通讯作者：
Balsam, P
影响因子：
3.7
作者：
Bagiella, E;Sloan, RP;Heitjan, DF
通讯作者：
Heitjan, DF
影响因子：
33.6
作者：
Wang XJ
通讯作者：
Wang XJ
感觉间选择性注意和时间定向并行运作，并在空间上不同的感觉和运动皮层中实例化
影响因子：
4.8
作者：
Pomper U;Keil J;Foxe JJ;Senkowski D
通讯作者：
Senkowski D