Dynamic Interactions of Transcription Factors and Enhancer Reprogramming in Cancer Progression.
Dynamic Interactions of Transcription Factors and Enhancer Reprogramming in Cancer Progression.
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DOI：
10.3389/fonc.2021.753051
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发表时间：
2021
影响因子：
4.7
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Zboril E;Yoo H;Chen L;Liu Z
虽然改进的肿瘤治疗显着降低了总体死亡率，但包括复发、治疗耐药和转移在内的侵袭性进展是癌症造成的大部分死亡的原因。增强子是重要的远端 DNA 调控元件，可在发育和其他生物过程中控制时间或空间特异性基因表达模式。全基因组测序揭示了癌症中增强子的频繁改变，远端增强子的重编程已成为肿瘤的重要特征之一。在这篇综述中，我们将讨论肿瘤进展相关的增强子动力学、其转录因子（TF）驱动因素以及增强子重编程如何在癌症侵袭进展过程中调节基因表达。此外，我们将探索当代技术的最新进展，包括单细胞测序、空间转录组学和 CUT&RUN，这些技术使得体内增强子重编程的综合研究成为可能。鉴于增强子动力学及其驱动因素在控制癌症进展和治疗结果中的重要作用，了解这些变化对于减轻侵袭性事件和发现新的治疗靶点至关重要。
While improved tumor treatment has significantly reduced the overall mortality rates, invasive progression including recurrence, therapy resistance and metastasis contributes to the majority of deaths caused by cancer. Enhancers are essential distal DNA regulatory elements that control temporal- or spatial-specific gene expression patterns during development and other biological processes. Genome-wide sequencing has revealed frequent alterations of enhancers in cancers and reprogramming of distal enhancers has emerged as one of the important features for tumors. In this review, we will discuss tumor progression-associated enhancer dynamics, its transcription factor (TF) drivers and how enhancer reprogramming modulates gene expression during cancer invasive progression. Additionally, we will explore recent advancements in contemporary technology including single-cell sequencing, spatial transcriptomics and CUT&RUN, which have permitted integrated studies of enhancer reprogramming in vivo. Given the essential roles of enhancer dynamics and its drivers in controlling cancer progression and treatment outcome, understanding these changes will be paramount in mitigating invasive events and discovering novel therapeutic targets.
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影响因子：
16
作者：
Calo, Eliezer;Wysocka, Joanna
通讯作者：
Wysocka, Joanna
影响因子：
30.8
作者：
Carroll, Jason S.;Meyer, Clifford A.;Brown, Myles
通讯作者：
Brown, Myles
影响因子：
64.5
作者：
Boija A;Klein IA;Sabari BR;Dall'Agnese A;Coffey EL;Zamudio AV;Li CH;Shrinivas K;Manteiga JC;Hannett NM;Abraham BJ;Afeyan LK;Guo YE;Rimel JK;Fant CB;Schuijers J;Lee TI;Taatjes DJ;Young RA
通讯作者：
Young RA
MYB-QKI重排在血管中心神经胶质瘤中通过三方机制驱动肿瘤性。
影响因子：
30.8
作者：
Bandopadhayay P;Ramkissoon LA;Jain P;Bergthold G;Wala J;Zeid R;Schumacher SE;Urbanski L;O'Rourke R;Gibson WJ;Pelton K;Ramkissoon SH;Han HJ;Zhu Y;Choudhari N;Silva A;Boucher K;Henn RE;Kang YJ;Knoff D;Paolella BR;Gladden-Young A;Varlet P;Pages M;Horowitz PM;Federation A;Malkin H;Tracy AA;Seepo S;Ducar M;Van Hummelen P;Santi M;Buccoliero AM;Scagnet M;Bowers DC;Giannini C;Puget S;Hawkins C;Tabori U;Klekner A;Bognar L;Burger PC;Eberhart C;Rodriguez FJ;Hill DA;Mueller S;Haas-Kogan DA;Phillips JJ;Santagata S;Stiles CD;Bradner JE;Jabado N;Goren A;Grill J;Ligon AH;Goumnerova L;Waanders AJ;Storm PB;Kieran MW;Ligon KL;Beroukhim R;Resnick AC
通讯作者：
Resnick AC
影响因子：
8.8
作者：
Bhagwat AS;Roe JS;Mok BYL;Hohmann AF;Shi J;Vakoc CR
通讯作者：
Vakoc CR