Infiltrated atrial fat characterizes underlying atrial fibrillation substrate in patients at risk as defined by the ARIC atrial fibrillation risk score.
Infiltrated atrial fat characterizes underlying atrial fibrillation substrate in patients at risk as defined by the ARIC atrial fibrillation risk score.
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DOI：
10.1016/j.ijcard.2014.01.012
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发表时间：
2014-03-01
影响因子：
3.5
通讯作者：
Lima, Joao A. C.
中科院分区：
文献类型：
--
作者：
Tereshchenk, Larisa G.;Rizzi, Patricia;Mewton, Nathan;Volpe, Gustavo Jardim;Murthy, Sindhoora;Strauss, David G.;Liu, Chia Y.;Marchlinski, Francis E.;Spooner, Peter;Berger, Ronald D.;Kellman, Peter;Lima, Joao A. C.
众所周知，扩张的心外膜脂肪与房颤（AF）相关。然而，浸润的心房内脂肪以前没有被量化的个人在风险确定的ARIC AF风险评分。窦性心律患者（N=90，年龄57± 10岁; 55名男性[63.2%]），根据ARIC AF风险评分确定的3组AF风险[低（≤11分; n=15）、中度（12-18分; n=40）、高（≥19分; n=23）AF风险]和阵发性AF（n=12）接受了心脏磁共振研究。在水平纵轴上，使用Dark-blood DIR制备的Fat-Water-separated序列分析心房内和心外膜脂肪。使用OsiriX DICOM查看器（日内瓦，瑞士）量化心房内脂肪面积。在卵圆窝水平测量房间隔头侧部分的宽度。在研究组中，心房内脂肪随着AF风险的增加而单调增加（低AF风险16±4 vs.中度AF风险32±18 vs.高AF风险81±83 mm 2; ANOVA P=0.012）。在校正性别、种族、左右心房面积指数和体重指数后，对数转换的心房内脂肪在多变量有序概率单位回归中预测ARIC AF风险评分（β系数0.50 [95%CI 0.03-0.97]; P=0.037），而心外膜脂肪则不能。房间隔宽度显示出类似的相关性（3.0±1.4 vs. 5.0±1.8 vs. 7.1±2.7 mm; ANOVA P<0.001;校正β系数2.80 [95%CI 1.19-4.41]; P=0.001）。心房内脂肪浸润是房颤风险个体基质演变的特征。
It is known that expanded epicardial fat is associated with atrial fibrillation (AF). However, infiltrated intraatrial fat has not been previously quantified in individuals at risk as determined by the ARIC AF risk score. Patients in sinus rhythm (N=90, age 57±10y; 55 men [63.2%]), in 3 groups at risk of AF as determined by the ARIC AF risk score [low (≤11 points; n=15), moderate (12–18 points; n=40), high (≥19 points; n=23) risk of AF], and paroxysmal AF (n=12) underwent cardiac magnetic resonance study. Intraatrial and epicardial fat was analyzed with a Dark-blood DIR-prepared Fat-Water-separated sequence in the horizontal longitudinal axis. OsiriX DICOM viewer (Geneva, Switzerland) was used to quantify the intraatrial fat area. Width of the cephalad portion of the interatrial septum was measured at the level of the fossa ovalis. Intraatrial fat monotonically increased with growing AF risk in study groups (low AF risk 16±4 vs. moderate AF risk 32±18 vs. high AF risk 81±83 mm2; ANOVA P=0.012). Log-transformed intraatrial fat predicted ARIC AF risk score in multivariate ordered probit regression after adjustment for sex, race, left and right atrial area indices, and body mass index (β-coefficient 0.50 [95%CI 0.03–0.97]; P=0.037), whereas epicardial fat did not. Interatrial septum width showed similar association (3.0±1.4 vs. 5.0±1.8 vs. 7.1±2.7 mm; ANOVA P<0.001; adjusted β-coefficient 2.80 [95%CI 1.19–4.41]; P=0.001). Infiltrated intraatrial fat characterizes evolving substrate in individuals at risk of AF.
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影响因子：
3.3
作者：
Kellman, Peter;Hernando, Diego;Shah, Saurabh;Zuehlsdorff, Sven;Jerecic, Renate;Mancini, Christine;Liang, Zhi-Pei.;Arai, Andrew E.
通讯作者：
Arai, Andrew E.
影响因子：
5.4
作者：
Alonso A;Krijthe BP;Aspelund T;Stepas KA;Pencina MJ;Moser CB;Sinner MF;Sotoodehnia N;Fontes JD;Janssens AC;Kronmal RA;Magnani JW;Witteman JC;Chamberlain AM;Lubitz SA;Schnabel RB;Agarwal SK;McManus DD;Ellinor PT;Larson MG;Burke GL;Launer LJ;Hofman A;Levy D;Gottdiener JS;Kääb S;Couper D;Harris TB;Soliman EZ;Stricker BH;Gudnason V;Heckbert SR;Benjamin EJ
通讯作者：
Benjamin EJ
影响因子：
9.6
作者：
Heyer, CM;Kagel, T;Nicolas, V
通讯作者：
Nicolas, V
影响因子：
24
作者：
Al Chekakie, M. Obadah;Welles, Christine C.;Akar, Joseph G.
通讯作者：
Akar, Joseph G.
影响因子：
37.8
作者：
Fuster, Valentin;Ryden, Lars E.;Wann, L. Samuel
通讯作者：
Wann, L. Samuel