Lymph node macrophages.

Lymph node macrophages.
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DOI:
10.1159/000337007
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发表时间:
2012
影响因子:
5.3
通讯作者:
Cyster JG
Cyster JG
中科院分区:
医学2区
文献类型:
--
作者:
Gray EE;Cyster JG

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淋巴结(LN)巨噬细胞长期以来因其能高效摄取淋巴携带的抗原而为人所知。对先天性和适应性免疫反应的一系列研究汇聚在一起,使得在理解它们更特殊的特性方面取得了令人兴奋的最新进展:向B细胞、树突状细胞和T细胞呈递抗原,产生营养因子和细胞因子,而且值得注意的是,允许病毒感染,这一特性对于引发抗病毒反应至关重要。淋巴结巨噬细胞传统上根据其位于被膜下窦和髓质的位置被分为不同的亚群。在此我们将淋巴结巨噬细胞分为三个亚群:被膜下窦巨噬细胞(SSMs)、髓质窦巨噬细胞(MSMs)和髓索巨噬细胞(MCMs)。我们综述了有关这些细胞在先天性和适应性免疫反应中的作用以及它们发育所需条件的文献。我们还讨论了与它们的纯化相关的挑战以及淋巴结巨噬细胞之间存在的其他异质性。
Lymph node (LN) macrophages have long been known for their efficient uptake of lymph-borne antigens. A convergence of studies on innate and adaptive immune responses has led to exciting recent advances in understanding their more specialized properties: presenting antigens to B cells, dendritic cells and T cells, producing trophic factors and cytokines, and, remarkably, being permissive for viral infection, a property critical for mounting anti-viral responses. LN macrophages have been traditionally divided into subsets based on their subcapsular sinus and medullary locations. Here we classify LN macrophages into three subsets: subcapsular sinus macrophages (SSMs), medullary sinus macrophages (MSMs) and medullary cord macrophages (MCMs). We review the literature regarding the roles of these cells in innate and adaptive immune responses and requirements for their development. We also discuss challenges associated with their purification as well as the existence of additional heterogeneity among LN macrophages.
感染期间淋巴结中中性粒细胞迁移的动态。
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发表时间: 1983-01-01
期刊: ANATOMY AND EMBRYOLOGY
影响因子: --
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