A longitudinal analysis of brain extracellular free water in HIV infected individuals.
A longitudinal analysis of brain extracellular free water in HIV infected individuals.
复制标题
DOI：
10.1038/s41598-021-87801-y
复制
发表时间：
2021-04-15
影响因子：
4.6
通讯作者：
Schifitto G
中科院分区：
文献类型：
--
作者：
Uddin MN;Faiyaz A;Wang L;Zhuang Y;Murray KD;Descoteaux M;Tivarus ME;Weber MT;Zhong J;Qiu X;Schifitto G
开始联合抗逆转录病毒疗法(CART)可减少艾滋病毒感染者(HIV+)的炎症。最近的研究表明，基于扩散磁共振成像的细胞外游离水(FW)模型对神经炎症反应敏感。在这里，我们调查了HIV感染中的FW，它的时间演变，以及它与血液标记物和认知评分的关系。使用96名年龄匹配的参与者，我们发现在基线时，与未感染艾滋病毒(艾滋病毒 )的人相比，单纯艾滋病毒+−患者的灰质和白质FW显著升高。这些增加的Fw值与神经丝轻链(NFL)呈正相关，与CD4计数呈负相关。经过12周的CART治疗后， 组的灰质和白质的FW以及NFL均下降。在1年和2年的随访中，HIV+ 组和HIV−组之间没有显著的FW差异。结果表明，幼稚的HIV+ 参与者的FW升高可能是由于神经炎症。FW和NFL之间的相关性，以及12周CART治疗后FW和NFL的改善进一步加强了这一结论。对1年和2年的较长时间的随访表明，根据FW的推断，CART有助于控制神经炎症。因此，FW可作为监测HIV相关神经炎症的生物标志物。
Initiation of combination antiretroviral therapy (cART) reduces inflammation in HIV-infected (HIV+) individuals. Recent studies demonstrated that diffusion MRI based extracellular free water (FW) modeling can be sensitive to neuroinflammation. Here, we investigate the FW in HIV-infection, its temporal evolution, and its association with blood markers, and cognitive scores. Using 96 age-matched participants, we found that FW was significantly elevated in grey and white matter in cART-naïve HIV+ compared to HIV-uninfected (HIV−) individuals at baseline. These increased FW values positively correlated with neurofilament light chain (NfL) and negatively correlated with CD4 counts. FW in grey and white matter, as well as NfL decreased in the HIV+ after 12 weeks of cART treatment. No significant FW differences were noted between the HIV+ and HIV− cohorts at 1 and 2-year follow-up. Results suggest that FW elevation in cART-naïve HIV+ participants is likely due to neuroinflammation. The correlation between FW and NfL, and the improvement in both FW and NfL after 12 weeks of cART treatment further reinforces this conclusion. The longer follow-up at 1 and 2 years suggests that cART helped control neuroinflammation as inferred by FW. Therefore, FW could be used as a biomarker to monitor HIV-associated neuroinflammation.
登录
查看更多内容
影响因子：
3.8
作者：
Abreu, Celina;Shirk, Erin N.;Clements, Janice E.
通讯作者：
Clements, Janice E.
DOI：
10.1097/qai.0b013e318249db17
发表时间：
2012-04-15
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Ances BM;Ortega M;Vaida F;Heaps J;Paul R
通讯作者：
Paul R
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
6
作者：
Andica, Christina;Kamagata, Koji;Aoki, Shigeki
通讯作者：
Aoki, Shigeki
影响因子：
3.8
作者：
Chang, Kevin;Premeaux, Thomas A.;Valcour, Victor
通讯作者：
Valcour, Victor