Gastrointestinal Biopsies for the Diagnosis of Alpha-Synuclein Pathology in Parkinson's Disease.
Gastrointestinal Biopsies for the Diagnosis of Alpha-Synuclein Pathology in Parkinson's Disease.
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DOI：
10.1155/2015/476041
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发表时间：
2015
影响因子：
2
通讯作者：
Cersosimo MG
中科院分区：
文献类型：
--
作者：
Cersosimo MG
帕金森病的诊断主要依靠临床表现，而病理学确诊则需要尸检。PD的神经病理学标志是神经元损失和受影响区域中存在称为路易体/神经突的内含物。这些内含物的主要成分是磷酸化的α-突触核蛋白（α-SYN）蛋白。有证据表明，α-SYN病理广泛分布于PD患者的中枢神经系统外。胃肠道受到含α-SYN包涵体的重要影响，并且病理分布通常存在吻尾梯度。最高量的路易体/神经突在下颌下腺和下食道中发现，最低量的路易体/神经突在直肠中发现。尸检结果促进了旨在通过证明这些外周可及组织的活检材料中存在α-SYN病理来实现PD体内病理诊断的研究。到目前为止，肠道活检研究已经证明唾液腺、胃、十二指肠、结肠和直肠中存在α-SYN病理。有必要进一步研究，以确定哪些是体内α-SYN病理检测的最敏感靶点，以及这些方法在PD患者中的最安全技术。
The diagnosis of Parkinson's disease (PD) relies on clinical features whereas pathological confirmation is only possible with autopsy examination. The neuropathological hallmarks of PD are neuronal loss and the presence of inclusions termed Lewy bodies/neurites in affected regions. A major component of these inclusions is phosphorylated alpha-synuclein (α-SYN) protein. There is evidence that α-SYN pathology is widely distributed outside the central nervous system in patients with PD. The gastrointestinal tract is importantly affected by α-SYN containing inclusions and typically there is a rostrocaudal gradient for the distribution of the pathology. The highest amounts of Lewy bodies/neurites are found at the submandibular gland together with the lower esophagus and the lowest amounts are found in the rectum. Autopsy findings prompted research aimed at achieving in vivo pathological diagnosis of PD by demonstrating the presence of α-SYN pathology in biopsy material of these peripheral accessible tissues. So far, biopsy studies of the gut have demonstrated the presence of α-SYN pathology in the salivary glands, stomach, duodenum, colon, and rectum. Further research is necessary in order to determine which are the most sensitive targets for in vivo α-SYN pathology detection and the safest techniques for these approaches in patients with PD.
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影响因子：
3.7
作者：
Lebouvier T;Neunlist M;Bruley des Varannes S;Coron E;Drouard A;N'Guyen JM;Chaumette T;Tasselli M;Paillusson S;Flamand M;Galmiche JP;Damier P;Derkinderen P
通讯作者：
Derkinderen P
影响因子：
2.5
作者：
Folgoas, Emmanuelle;Lebouvier, Thibaud;Letournel, Franck
通讯作者：
Letournel, Franck
影响因子：
12.7
作者：
Beekes M;Thomzig A;Schulz-Schaeffer WJ;Burger R
通讯作者：
Burger R
影响因子：
5
作者：
Kalaitzakis, M. E.;Graeber, M. B.;Pearce, R. K. B.
通讯作者：
Pearce, R. K. B.
影响因子：
6
作者：
Cersosimo, Maria G.;Raina, Gabriela B.;Benarroch, Eduardo E.
通讯作者：
Benarroch, Eduardo E.