Association between physical activity and risk of all-cause mortality and cardiovascular disease in patients with diabetes: a meta-analysis.
Association between physical activity and risk of all-cause mortality and cardiovascular disease in patients with diabetes: a meta-analysis.
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DOI：
10.2337/dc12-0783
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发表时间：
2013-02
期刊：
影响因子：
16.2
通讯作者：
Sone H
中科院分区：
文献类型：
--
作者：
Kodama S;Tanaka S;Heianza Y;Fujihara K;Horikawa C;Shimano H;Saito K;Yamada N;Ohashi Y;Sone H
在糖尿病患者中，习惯性体力活动(PA)与降低全因死亡率(ACM)和心血管疾病(CVD)的风险之间存在关联。这项荟萃分析总结了与PA相关的风险降低，重点是阐明剂量-反应关系。电子文献检索用于队列研究，检查糖尿病患者ACM或CVD与PA的相对风险(RR)。对于定性评估，每个研究中最高PA类别与最低PA类别的RR用随机效应模型合并。我们增加了线性和样条回归分析来评估PA和ACM增加与CVD风险之间的定量关系。符合条件的研究有17项。定性上，PA分级最高的患者ACM(0.61[0.52~0.70])和CVD(0.71[0.60~0.84])的RR[95%CI]低于PA分级最低的患者。线性回归模型对急性心肌梗死(调整后R2=0.44，P=0.001)和心血管疾病(调整后R2=0.51，P=0.001)的风险有较高的拟合度，结果表明，每天递增1Met-h的PA分别使急性心肌梗死和心血管疾病的风险降低9.5%(5.0-13.8%)和7.9%(4.3-11.4%)。在拟合优度方面，样条回归模型与线性模型无显著差异(ACM风险P=0.14；心血管风险P=0.60)。在糖尿病患者中，PA越多，未来ACM和心血管疾病的风险降低越大。然而，任何数量的习惯性PA都比不活动要好。
The association between habitual physical activity (PA) and lowered risk of all-cause mortality (ACM) and cardiovascular disease (CVD) has been suggested in patients with diabetes. This meta-analysis summarizes the risk reduction in relation to PA, focusing on clarifying dose-response associations. Electronic literature searches were conducted for cohort studies that examined relative risk (RR) of ACM or CVD in relation to PA in patients with diabetes. For the qualitative assessment, RR for the highest versus the lowest PA category in each study was pooled with a random-effects model. We added linear and spline regression analyses to assess the quantitative relationship between increases in PA and ACM and CVD risk. There were 17 eligible studies. Qualitatively, the highest PA category had a lower RR [95% CI] for ACM (0.61 [0.52–0.70]) and CVD (0.71 [0.60–0.84]) than the lowest PA category. The linear regression model indicated a high goodness of fit for the risk of ACM (adjusted R2 = 0.44, P = 0.001) and CVD (adjusted R2 = 0.51, P = 0.001), with the result that a 1 MET-h/day incrementally higher PA was associated with 9.5% (5.0–13.8%) and 7.9% (4.3–11.4%) reductions in ACM and CVD risk, respectively. The spline regression model was not significantly different from the linear model in goodness of fit (P = 0.14 for ACM risk; P = 0.60 for CVD risk). More PA was associated with a larger reduction in future ACM and CVD risk in patients with diabetes. Nevertheless, any amount of habitual PA was better than inactivity.
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影响因子：
1.9
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
16.2
作者：
Gregg EW;Cheng YJ;Saydah S;Cowie C;Garfield S;Geiss L;Barker L
通讯作者：
Barker L
影响因子：
2.5
作者：
Shinji, S.;Shigeru, M.;Shigehiro, K.
通讯作者：
Shigehiro, K.
影响因子：
8.2
作者：
Praet, S. F. E.;van Rooij, E. S. J.;Wijtvliet, A.;Boonman-de Winter, L. J. M.;Enneking, Th.;Kuipers, H.;Stehouwer, C. D. A.;van Loon, L. J. C.
通讯作者：
van Loon, L. J. C.