Coping Strategies, Neural Structure, and Depression and Anxiety During the COVID-19 Pandemic: A Longitudinal Study in a Naturalistic Sample Spanning Clinical Diagnoses and Subclinical Symptoms.
Coping Strategies, Neural Structure, and Depression and Anxiety During the COVID-19 Pandemic: A Longitudinal Study in a Naturalistic Sample Spanning Clinical Diagnoses and Subclinical Symptoms.
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DOI：
10.1016/j.bpsgos.2021.06.007
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Williams LM
中科院分区：
文献类型：
--
作者：
Holt-Gosselin B;Tozzi L;Ramirez CA;Gotlib IH;Williams LM
尽管 COVID-19 大流行已被证明会加剧焦虑和抑郁症状，但我们不知道哪些行为和神经因素可以减轻这种影响。为了解决这一差距，我们评估了适应性和适应不良的应对策略是否会影响大流行期间的症状轨迹。我们还研究了大流行前与抑郁和焦虑有关的大脑区域的完整性是否会影响大流行症状。在涵盖精神科诊断和亚临床症状的 169 名成年人（66.9% 女性；年龄 19-74 岁）的自然样本中，我们使用经过验证的成分（21 项抑郁、焦虑和压力量表）、应对策略（经历问题的简要应对方向）以及灰质体积（杏仁核）和皮质来评估快感缺乏、紧张和焦虑唤醒症状磁共振成像 T1 加权扫描的厚度（海马体、岛叶、前扣带皮层）。我们建立了一般线性混合效应模型来测试预先注册的假设：1）大流行前适应不良的应对方式；2）大流行前较低的结构完整性将预测更严重的大流行症状； 3）应对会与神经结构相互作用以预测流行病症状。在大流行期间，更多地使用适应不良的应对策略与更严重的焦虑唤醒症状相关（p = .011，错误发现率校正 p [pFDR] = .035），特别是更少的自我分心（p = .014，pFDR = .042）和更大的自责（p = .002，pFDR = .012）。大流行前岛叶厚度减少预示着更严重的焦虑唤醒症状（p = .001，pFDR = .027）。自我分心与杏仁核体积相互作用来预测快感缺乏症状（p = .005，pFDR = .020）。适应不良的应对策略和大脑区域的结构变化可能会影响长期压力事件（例如，COVID-19 大流行）期间的临床症状。未来的研究需要确定与应对全球健康危机有关的行为和神经因素，以增强抵御能力。
Although the COVID-19 pandemic has been shown to worsen anxiety and depression symptoms, we do not understand which behavioral and neural factors may mitigate this impact. To address this gap, we assessed whether adaptive and maladaptive coping strategies affect symptom trajectory during the pandemic. We also examined whether pre-pandemic integrity of brain regions implicated in depression and anxiety affect pandemic symptoms. In a naturalistic sample of 169 adults (66.9% female; age 19–74 years) spanning psychiatric diagnoses and subclinical symptoms, we assessed anhedonia, tension, and anxious arousal symptoms using validated components (21-item Depression, Anxiety, and Stress Scale), coping strategies (Brief–Coping Orientation to Problems Experienced), and gray matter volume (amygdala) and cortical thickness (hippocampus, insula, anterior cingulate cortex) from magnetic resonance imaging T1-weighted scans. We conducted general linear mixed-effects models to test preregistered hypotheses that 1) maladaptive coping pre-pandemic and 2) lower structural integrity pre-pandemic would predict more severe pandemic symptoms; and 3) coping would interact with neural structure to predict pandemic symptoms. Greater use of maladaptive coping strategies was associated with more severe anxious arousal symptoms during the pandemic (p = .011, false discovery rate–corrected p [pFDR] = .035), specifically less self-distraction (p = .014, pFDR = .042) and greater self-blame (p = .002, pFDR = .012). Reduced insula thickness pre-pandemic predicted more severe anxious arousal symptoms (p = .001, pFDR = .027). Self-distraction interacted with amygdala volume to predict anhedonia symptoms (p = .005, pFDR = .020). Maladaptive coping strategies and structural variation in brain regions may influence clinical symptoms during a prolonged stressful event (e.g., COVID-19 pandemic). Future studies that identify behavioral and neural factors implicated in responses to global health crises are warranted for fostering resilience.
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作者：
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影响因子：
4.7
作者：
Chalmers JA;Quintana DS;Abbott MJ;Kemp AH
通讯作者：
Kemp AH
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y