Aspirin locally disrupts the liquid-ordered phase.
Aspirin locally disrupts the liquid-ordered phase.
复制标题
DOI：
10.1098/rsos.171710
复制
发表时间：
2018-03
影响因子：
3.5
通讯作者：
Rheinstädter MC
中科院分区：
文献类型：
--
作者：
Alsop RJ;Himbert S;Dhaliwal A;Schmalzl K;Rheinstädter MC
脂膜的局部结构和动力学在膜功能中起重要作用。小分子的扩散，蛋白质周围脂质的曲率和富含胆固醇的脂质结构域（筏）的存在是膜作为功能界面的例子。特别是脂质尾部的集体波动与膜成分和小分子在膜中和跨膜的扩散以及膜结构域的结构和形成有关。我们研究了阿司匹林（乙酰水杨酸，阿萨）对由二肉豆蔻酰磷酸胆碱（DMPC）和胆固醇组成的膜的局部结构和动力学的影响。阿司匹林是一种常见的止痛药，但也用于治疗胆固醇。使用相干非弹性中子散射实验和分子动力学（MD）模拟，我们提出的证据表明，阿萨绑定到液体有序，筏状域和扰乱域组织和抑制集体波动。通过与脂质分子形成氢键，阿萨与脂质分子形成“超流体”复合物，可以在超晶格中横向组织并抑制胆固醇的有序效应。
Local structure and dynamics of lipid membranes play an important role in membrane function. The diffusion of small molecules, the curvature of lipids around a protein and the existence of cholesterol-rich lipid domains (rafts) are examples for the membrane to serve as a functional interface. The collective fluctuations of lipid tails, in particular, are relevant for diffusion of membrane constituents and small molecules in and across membranes, and for structure and formation of membrane domains. We studied the effect of aspirin (acetylsalicylic acid, ASA) on local structure and dynamics of membranes composed of dimyristoylphosphocholine (DMPC) and cholesterol. Aspirin is a common analgesic, but is also used in the treatment of cholesterol. Using coherent inelastic neutron scattering experiments and molecular dynamics (MD) simulations, we present evidence that ASA binds to liquid-ordered, raft-like domains and disturbs domain organization and dampens collective fluctuations. By hydrogen-bonding to lipid molecules, ASA forms ‘superfluid’ complexes with lipid molecules that can organize laterally in superlattices and suppress cholesterol’s ordering effect.
登录
查看更多内容
影响因子：
3.4
作者：
Dies, Hannah;Cheung, Bonnie;Rheinstaedter, Maikel C.
通讯作者：
Rheinstaedter, Maikel C.
影响因子：
8.6
作者：
Chen, SH;Liao, CY;Sette, F
通讯作者：
Sette, F
影响因子：
4.6
作者：
Himbert, Sebastian;Alsop, Richard J.;Rheinstadter, Maikel C.
通讯作者：
Rheinstadter, Maikel C.
影响因子：
3.4
作者：
Armstrong, C. L.;Trapp, M.;Rheinstaedter, M. C.
通讯作者：
Rheinstaedter, M. C.
影响因子：
64.8
作者：
Eggeling, Christian;Ringemann, Christian;Hell, Stefan W.
通讯作者：
Hell, Stefan W.