The effect of Mg-Ca-Sr alloy degradation products on human mesenchymal stem cells.
The effect of Mg-Ca-Sr alloy degradation products on human mesenchymal stem cells.
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DOI：
10.1002/jbm.b.33869
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Manuel MV
中科院分区：
文献类型：
--
作者：
Berglund IS;Dirr EW;Ramaswamy V;Allen JB;Allen KD;Manuel MV
可生物降解的镁合金有潜力取代目前使用的金属医疗植入装置，可能消除毒性问题和二次手术的需要，同时还为组织生长提供潜在的刺激环境。最近开发的 Mg-Ca-Sr 合金比其他镁合金具有优越的特性，具有强度和降解行为的良好结合，同时还表现出潜在的成骨特性。为了更好地了解合金降解产物对细胞机制的影响，使用人骨髓间充质干细胞进行了体外研究。合金溶解的离子产物被发现是无毒的，但改变了干细胞的增殖特征。此外，它们的存在改变了成骨发育的进程，而镁的浓度尤其可以诱导干细胞分化。本文提出的工作为未来的合金设计奠定了基础，可以定制结构以获得特定的植入物性能。这些潜在的生物活性植入物将通过缩短患者的愈合时间、最大限度地减少不适和毒性问题来降低患者的风险，同时降低医院费用。 © 2017 The Authors Journal of Biomedical Materials Research Part B：Applied Biomaterials Published by Wiley periodicals, Inc. J Biomed Mater Res Part B：Appl Biomater，106B：697–704，2018。
Biodegradable Mg alloys have the potential to replace currently used metallic medical implant devices, likely eliminating toxicity concerns and the need for secondary surgeries, while also providing a potentially stimulating environment for tissue growth. A recently developed Mg–Ca–Sr alloy possesses advantageous characteristics over other Mg alloys, having a good combination of strength and degradation behavior, while also displaying potentially osteogenic properties. To better understand the effect of alloy degradation products on cellular mechanisms, in vitro studies using human bone marrow‐derived mesenchymal stem cells were conducted. Ionic products of alloy dissolution were found to be nontoxic but changed the proliferation profile of stem cells. Furthermore, their presence changed the progress of osteogenic development, while concentrations of Mg in particular appeared to induce stem cell differentiation. The work presented herein provides a foundation for future alloy design where structures can be tailored to obtain specific implant performance. These potentially bioactive implants would reduce the risks for patients by shortening their healing time, minimizing discomfort and toxicity concerns, while reducing hospital costs. © 2017 The Authors Journal of Biomedical Materials Research Part B: Applied Biomaterials Published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 697–704, 2018.
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影响因子：
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作者：
Tonelli, Fernanda M. P.;Santos, Anderson K.;Gomes, Dawidson A.;da Silva, Saulo L.;Gomes, Katia N.;Ladeira, Luiz O.;Resende, Rodrigo R.
通讯作者：
Resende, Rodrigo R.
影响因子：
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DOI：
10.1016/j.bbrc.2012.01.088
发表时间：
2012-02-24
影响因子：
3.1
作者：
Li, Yunfeng;Li, Jihua;Hu, Jing
通讯作者：
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DOI：
10.1007/s10856-010-4022-8
发表时间：
2010-05-01
影响因子：
3.7
作者：
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通讯作者：
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