Stem cells and calcium signaling.
Stem cells and calcium signaling.
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DOI：
10.1007/978-94-007-2888-2_40
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发表时间：
2012
影响因子：
--
通讯作者：
Resende, Rodrigo R.
中科院分区：
文献类型：
--
作者：
Tonelli, Fernanda M. P.;Santos, Anderson K.;Gomes, Dawidson A.;da Silva, Saulo L.;Gomes, Katia N.;Ladeira, Luiz O.;Resende, Rodrigo R.
关键词：
对干细胞研究的兴趣越来越大，这与开发许多危及生命、使人衰弱的疾病的治疗方法和细胞替代疗法的前景有关。然而，只有当达到关于促进所需细胞命运的分子信号的准确知识时，才有可能安全地进行这些治疗创新。在这些信号中有细胞内Ca 2+浓度[Ca 2 +]i的瞬时变化。作为细胞内的信使，Ca 2+在干细胞的各个分化阶段的细胞信号通路中起着关键作用。本章的目的是提出一个广泛的概述各种时刻，其中钙离子介导的信号是必不可少的维持干细胞和促进他们的发展和分化，也专注于他们的治疗潜力。
The increasing interest in stem cell research is linked to the promise of developing treatments for many lifethreatening, debilitating diseases, and for cell replacement therapies. However, performing these therapeutic innovations with safety will only be possible when an accurate knowledge about the molecular signals that promote the desired cell fate is reached. Among these signals are transient changes in intracellular Ca2+ concentration [Ca2+]i. Acting as an intracellular messenger, Ca2+ has a key role in cell signaling pathways in various differentiation stages of stem cells. The aim of this chapter is to present a broad overview of various moments in which Ca2+-mediated signaling is essential for the maintenance of stem cells and for promoting their development and differentiation, also focusing on their therapeutic potential.
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DOI：
10.1073/pnas.95.26.15735
发表时间：
1998-12-22
影响因子：
11.1
作者：
Cotrina, ML;Lin, JHC;Nedergaard, M
通讯作者：
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影响因子：
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DOI：
10.1073/pnas.1536783100
发表时间：
2003-07-22
影响因子：
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影响因子：
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作者：
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影响因子：
9.2
作者：
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