Lower serum 25-hydroxycholecalciferol is associated with depressive symptoms in older adults in Southern Brazil.
Lower serum 25-hydroxycholecalciferol is associated with depressive symptoms in older adults in Southern Brazil.
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DOI：
10.1186/s12937-020-00638-5
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发表时间：
2020-11-14
影响因子：
5.4
通讯作者：
Moreira JD
中科院分区：
文献类型：
--
作者：
Ceolin G;Matsuo LH;Confortin SC;D'Orsi E;Rieger DK;Moreira JD
老年人是最容易患抑郁症的人群之一，特别是生活在低收入和中等收入国家的老年人。同时，他们也在考虑维生素D缺乏症的风险群体。低血清维生素D与脑神经精神障碍的风险增加有关。我们的目的是调查来自巴西南部的60岁及以上的成年人血清25-羟基胆钙化醇浓度和抑郁症状之间的关系。使用2013-2014年期间从基于人群的纵向EpiFloripa老化研究（n = 1197）中收集的数据进行横断面分析。根据内分泌学会参考值[充足（≥ 30 ng/mL）、不足（21-29 ng/mL）和缺乏（≤ 20 ng/mL）]分析血清25-羟基胆钙化醇浓度并进行分类。使用老年抑郁量表（15项GDS）评估抑郁症状。进行逻辑回归以评估每个维生素D类别的抑郁症状。该分析调整了性别，年龄，肤色，家庭收入，闲暇时间的体育活动，社会或宗教团体的出席，发病率，认知障碍和日常生活活动的依赖性。共有557名具有完整暴露和结局数据的参与者入组分析。大多数样本参与者为女性（63.1%），年龄范围为60-69岁（42.2%），肤色为白色（85.1%），维生素D血清水平样本在秋季采集（50.7%）。15.8%的受试者存在抑郁症状，维生素D缺乏（23.2，95%置信区间[CI] = 15.6;32.9）和维生素D不足（17.2，95%CI = 11.0;25.9）的患病率较高。粗略分析显示，维生素D缺乏的参与者出现抑郁症状的几率是维生素D充足的参与者的3.08倍（CI = 1.53;6.20）。调整后，相关性维持[OR 2.27（95%CI = 1.05;4.94）。血清25-羟胆钙化醇缺乏症与巴西南部老年人的抑郁症状呈正相关。
Older adults are one of the most susceptible populations to depression, especially those living in low- and middle-income countries. As well, they are also considering a risk group for vitamin D deficiency. Low serum vitamin D has been associated with an increased risk of brain neuropsychiatry disorders. We aimed to investigate the association between serum 25-hydroxycholecalciferol concentrations and depressive symptoms in adults aged 60 years and over from southern Brazil. A cross-sectional analysis was performed using data collected during 2013–2014 from the populational-based longitudinal EpiFloripa Aging Study (n = 1197). Serum 25-hydroxycholecalciferol concentrations were analyzed and classified according to the Endocrine Society reference values [sufficiency (≥ 30 ng/mL), insufficiency (21–29 ng/mL), and deficiency (≤ 20 ng/mL)]. Depressive symptoms were evaluated using the Geriatric Depression Scale (15-item GDS). Logistic regression was performed to assess depressive symptoms in each vitamin D category. The analysis was adjusted for sex, age, skin color, family income, leisure-time physical activities, social or religious groups attendance, morbidities, cognitive impairment, and dependence in activities of daily living. A total of 557 participants with complete data for exposure and outcome were enrolled in the analysis. Most of the sample participants were female (63.1%), age-range 60–69 years (42.2%), white skin color (85.1%), and vitamin D serum level samples were collected in autumn (50.7%). Depressive symptoms were present in 15.8% of the participants, and the prevalence was higher in individuals classified as deficient in vitamin D (23.2, 95% confidence interval [CI] = 15.6;32.9) and insufficiency (17.2, 95%CI = 11.0;25.9). The crude analysis showed that vitamin D deficient participants had 3.08 (CI = 1.53;6.20) times higher odds to present depressive symptoms compared to vitamin D sufficiency. After adjusting, the association was maintained [OR 2.27 (95%CI = 1.05;4.94). Serum 25-hydroxycholecalciferol deficiency was positively associated with depressive symptoms in older adults from southern Brazil.
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影响因子：
4.9
作者：
Almeida, Osvaldo P.;Hankey, Graeme J.;Flicker, Leon
通讯作者：
Flicker, Leon
DOI：
10.1590/1414-462x201900020169
发表时间：
2019-06-01
期刊：
Cadernos Saúde Coletiva
影响因子：
--
作者：
Confortin, Susana Cararo;Schneider, Ione Jayce Ceola;d’Orsi, Eleonora
通讯作者：
d’Orsi, Eleonora
DOI：
10.11606/s1518-8787.2017051006776
发表时间：
2017-01-01
期刊：
Revista de Saúde Pública
影响因子：
--
作者：
Schneider, Ione Jayce Ceola;Confortin, Susana Cararo;d’Orsi, Eleonora
通讯作者：
d’Orsi, Eleonora
影响因子：
5
作者：
Brouwer-Brolsma EM;Dhonukshe-Rutten RA;van Wijngaarden JP;van der Zwaluw NL;Sohl E;In't Veld PH;van Dijk SC;Swart KM;Enneman AW;Ham AC;van Schoor NM;van der Velde N;Uitterlinden AG;Lips P;Feskens EJ;de Groot LC
通讯作者：
de Groot LC
影响因子：
1.4
作者：
Almeida, OP;Almeida, SA
通讯作者：
Almeida, SA