Postpartum breast involution reveals regression of secretory lobules mediated by tissue-remodeling.
Postpartum breast involution reveals regression of secretory lobules mediated by tissue-remodeling.
复制标题
产后乳房的相互作用揭示了组织造型介导的分泌小叶的消退。
DOI：
10.1186/bcr3633
复制
发表时间：
2014-03-28
期刊：
影响因子：
--
通讯作者：
Schedin P
中科院分区：
文献类型：
--
作者：
Jindal S;Gao D;Bell P;Albrektsen G;Edgerton SM;Ambrosone CB;Thor AD;Borges VF;Schedin P
产后诊断乳腺癌是转移的独立预测因素，但原因尚不清楚。在啮齿动物中，产后乳腺退缩的窗口促进了肿瘤的进展，这表明乳房退缩在人类产后乳腺癌预后不良中发挥了作用。啮齿动物乳腺退化的特征是为哺乳准备的分泌小叶的程序性消除。这种组织退化过程涉及大量的上皮细胞死亡、间质重塑和免疫细胞的渗透，与伤口愈合和肿瘤进展过程中存在的微环境相似。在这里，我们对有已知生育史的绝经前妇女的乳腺组织进行表征，以确定妇女产后小叶退化的范围、持续时间和细胞机制。对20~45岁绝经前妇女(n = 183)的癌旁正常乳腺组织，按未分娩、妊娠、哺乳期、末次分娩时间分组，用计算机辅助定量方法进行组织学和小叶面积、小叶类型组成、细胞凋亡和免疫细胞浸润的特殊染色。人的无产腺主要由小叶(每个小叶约10个腺泡)和中等大小的小叶(每个小叶约35个腺泡)组成。在妊娠和哺乳期，乳房上皮面积是未分娩病例的10倍，乳腺腺主要由成熟的小叶(每个小叶100个腺泡)组成，具有分泌形态。产后12个月内，乳房上皮区和成熟小叶表型明显减少。到产后18个月时，小叶面积含量和小叶组成与未分娩的病例无法区分，这与产后复旧的数据一致，有利于为哺乳准备而形成的分泌小叶的消退。对细胞凋亡和免疫细胞渗入的分析证实，人类产后乳房退化的特点是伤口愈合样的组织重塑程序在较短的时间范围内发生。人类产后乳房退化是一种主要的组织重塑过程，将腺体的小叶总面积恢复到与未分娩的腺体基本无法区分的水平。产后复旧的正常生理过程是否导致产后乳腺癌预后不良，有待进一步研究。
A postpartum diagnosis of breast cancer is an independent predictor of metastases, however the reason is unknown. In rodents, the window of postpartum mammary gland involution promotes tumor progression, suggesting a role for breast involution in the poor prognosis of human postpartum breast cancers. Rodent mammary gland involution is characterized by the programmed elimination of the secretory lobules laid down in preparation for lactation. This tissue involution process involves massive epithelial cell death, stromal remodeling, and immune cell infiltration with similarities to microenvironments present during wound healing and tumor progression. Here, we characterize breast tissue from premenopausal women with known reproductive histories to determine the extent, duration and cellular mechanisms of postpartum lobular involution in women. Adjacent normal breast tissues from premenopausal women (n = 183) aged 20 to 45 years, grouped by reproductive categories of nulliparous, pregnant and lactating, and by time since last delivery were evaluated histologically and by special stain for lobular area, lobular type composition, apoptosis and immune cell infiltration using computer assisted quantitative methods. Human nulliparous glands were composed dominantly of small (approximately 10 acini per lobule) and medium (approximately 35 acini per lobule) sized lobules. With pregnancy and lactation, a >10 fold increase in breast epithelial area was observed compared to nulliparous cases, and lactating glands were dominated by mature lobules (>100 acini per lobule) with secretory morphology. Significant losses in mammary epithelial area and mature lobule phenotypes were observed within 12 months postpartum. By 18 months postpartum, lobular area content and lobule composition were indistinguishable from nulliparous cases, data consistent with postpartum involution facilitating regression of the secretory lobules developed in preparation for lactation. Analyses of apoptosis and immune cell infiltrate confirmed that human postpartum breast involution is characterized by wound healing-like tissue remodeling programs that occur within a narrowed time frame. Human postpartum breast involution is a dominant tissue-remodeling process that returns the total lobular area of the gland to a level essentially indistinguishable from the nulliparous gland. Further research is warranted to determine whether the normal physiologic process of postpartum involution contributes to the poor prognosis of postpartum breast cancer.
登录
查看更多内容
影响因子：
5.4
作者：
ALBREKTSEN, G;HEUCH, I;KVALE, G
通讯作者：
KVALE, G
影响因子：
5
作者：
Chie, WC;Hsieh, CC;MacMahon, B
通讯作者：
MacMahon, B
影响因子：
0.7
作者：
Borges, Virginia F.;Schedin, Pepper
通讯作者：
Schedin, Pepper
影响因子：
6
作者：
Conklin, Matthew W.;Eickhoff, Jens C.;Keely, Patricia J.
通讯作者：
Keely, Patricia J.
影响因子：
82.9
作者：
通讯作者：
--