The impact of elevated body mass on brain responses during appetitive prediction error in postpartum women.
The impact of elevated body mass on brain responses during appetitive prediction error in postpartum women.
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DOI：
10.1016/j.physbeh.2019.04.009
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发表时间：
2019-07-01
影响因子：
2.9
通讯作者：
Burger KS
中科院分区：
文献类型：
--
作者：
Shearrer GE;Nansel TR;Lipsky LM;Sadler JR;Burger KS
反复接触高可口的食物和体重增加促进：1）纹状体区域对惩罚不敏感，2）增加为食物工作的意愿。我们假设BMI与枕叶皮质的负预测误差BOLD反应呈正相关。此外，我们假设食物强化值将与眶额叶皮层和杏仁核的负预测误差BOLD反应呈负相关。产后妇女（n=47; BMI= 25.5±5.1）被“训练”将特定的线索与非常可口的奶昔或次可口的奶昔配对。然后，我们在40%的试验中违反了这些线索-味道配对，显示了一个可口的线索，然后是次可口的味道（负预测误差）。与我们的假设相反，在负预测误差（不匹配的提示-味觉）与匹配的可口提示-味觉之间，女性在中央盖（pFWE=0.002; k=1680; MNI：-57，-7，14）和中央后回（pFWE=0.006，k=1219; MNI：62，-8，18）中表现出更高的BOLD反应。当比较匹配的次可口提示-味觉与负预测误差试验时，BOLD反应在中央后回（r =-0.60，pFWE=0.008）、壳核（r =-0.55，pFWE=0.02）和海马（r =-0.50，pFWE=0.01）中增加。类似地，观察可口线索与次可口线索与壳核（pFWE=0.025，k=53; MNI：-20，6，-8）和杏仁核（pFWE=0.04，k=19，MNI：38，-12，-6）中的BOLD反应有关。产后6个月的BMI和食物强化值都与BOLD反应无关。皮层和壳核似乎编码视觉食物线索处理，味觉和体感皮层似乎编码负预测错误。躯体感觉皮层对匹配的线索-味觉对负预测误差的不同反应可能表明，可口的线索可能会使刺激物中的厌恶品质变钝。
Repeated exposure to highly palatable foods and elevated weight promote: 1) insensitivity to punishment in striatal regions and, 2) increased willingness to work for food. We hypothesized that BMI would be positively associated with negative prediction error BOLD response in the occipital cortex. Additionally, we postulated that food reinforcement value would be negatively associated with negative prediction error BOLD response in the orbital frontal cortex and amygdala. Postpartum women (n=47; BMI= 25.5±5.1) were ‘trained’ to associate specific cues paired to either a highly palatable milkshake or a sub-palatable milkshake. We then violated these cue-taste pairings in 40% of the trials by showing a palatable cue followed by the sub-palatable taste (negative prediction error). Contrary to our hypotheses, during negative prediction error (mismatched cue-taste) versus matched palatable cue-taste, women showed increased BOLD response in the central operculum (pFWE=0.002; k=1680; MNI: −57, −7,14) and postcentral gyrus (pFWE=0.006, k=1219; MNI: 62, −8,18). When comparing the matched sub-palatable cue-taste to the negative prediction error trials, BOLD response increased in the postcentral gyrus (r = −0.60, pFWE=0.008), putamen (r = −0.55, pFWE=0.02), and insula (r = −0.50, pFWE=0.01). Similarly, viewing the palatable cue vs sub-palatable cue was related to BOLD response in the putamen (pFWE=0.025, k=53; MNI: −20, 6, −8) and the insula (pFWE=0.04, k=19, MNI:38, −12, −6). Neither BMI at 6-month postpartum nor food reinforcement value was related to BOLD response. The insula and putamen appear to encode for visual food cue processing, and the gustatory and somatosensory cortices appear to encode negative prediction errors. Differential response in the somatosensory cortex to the matched cue-taste pairs to negative prediction error may indicate that a palatable cue may dull aversive qualities in the stimulus.
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DOI：
10.1073/pnas.1014269108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Glimcher, Paul W.
通讯作者：
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影响因子：
7.6
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影响因子：
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影响因子：
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影响因子：
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