Breast Milk Prefusion F Immunoglobulin G as a Correlate of Protection Against Respiratory Syncytial Virus Acute Respiratory Illness.
Breast Milk Prefusion F Immunoglobulin G as a Correlate of Protection Against Respiratory Syncytial Virus Acute Respiratory Illness.
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DOI：
10.1093/infdis/jiy477
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Chu HY
中科院分区：
文献类型：
--
作者：
Mazur NI;Horsley NM;Englund JA;Nederend M;Magaret A;Kumar A;Jacobino SR;de Haan CAM;Khatry SK;LeClerq SC;Steinhoff MC;Tielsch JM;Katz J;Graham BS;Bont LJ;Leusen JHW;Chu HY
经胎盘呼吸道合胞病毒（RSV）抗体转移的特点，但很少有人知道母乳RSV特异性抗体的保护作用。抗融合前RSV融合蛋白（pre-F）的血清抗体表现出高中和活性。我们研究母乳前F抗体对RSV急性呼吸道感染（ARI）的保护作用。在尼泊尔的母婴对中收集了产后1、3和6个月的母乳和婴儿疾病发作期间的中鼻拭子。174例有和无RSV ARI的婴儿按RSV ARI的危险因素1：1匹配。测量母乳中的Pre-F免疫球蛋白A（伊加）和免疫球蛋白G（IgG）抗体水平。患有RSV ARI婴儿的母亲患病前母乳前F IgG抗体中位浓度（1.4 [四分位距{IQR}，1.1-1.6] log 10 ng/mL）低于未患有RSV ARI婴儿的母亲（1.5 [IQR，1.3-1.8] log 10 ng/mL）（P = .001）。病例组与对照组的母体前F伊加抗体浓度中位数无差异（分别为1.7 [IQR，0.0-2.2] log 10 ng/mL vs 1.7 [IQR，1.2-2.2] log 10 ng/mL; P = 0.58）。RSV ARI前母乳前F IgG抗体水平较低，支持前F IgG作为RSV ARI保护相关物的潜在作用。母乳前F IgG的诱导可能是母体RSV疫苗的保护机制。呼吸道合胞病毒（RSV）急性呼吸道感染（ARI）前母乳预融合（pre-F）免疫球蛋白G（IgG）抗体水平低支持pre-F IgG作为RSV ARI保护相关物的潜在作用。母乳前F IgG的诱导可能是母体RSV疫苗的保护机制。
Transplacental respiratory syncytial virus (RSV) antibody transfer has been characterized, but little is known about the protective effect of breast milk RSV-specific antibodies. Serum antibodies against the prefusion RSV fusion protein (pre-F) exhibit high neutralizing activity. We investigate protection of breast milk pre-F antibodies against RSV acute respiratory infection (ARI). Breast milk at 1, 3, and 6 months postpartum and midnasal swabs during infant illness episodes were collected in mother–infant pairs in Nepal. One hundred seventy-four infants with and without RSV ARI were matched 1:1 by risk factors for RSV ARI. Pre-F immunoglobulin A (IgA) and immunoglobulin G (IgG) antibody levels were measured in breast milk. The median breast milk pre-F IgG antibody concentration before illness was lower in mothers of infants with RSV ARI (1.4 [interquartile range {IQR}, 1.1–1.6] log10 ng/mL) than without RSV ARI (1.5 [IQR, 1.3–1.8] log10 ng/mL) (P = .001). There was no difference in median maternal pre-F IgA antibody concentrations in cases vs controls (1.7 [IQR, 0.0–2.2] log10 ng/mL vs 1.7 [IQR, 1.2–2.2] log10 ng/mL, respectively; P = .58). Low breast milk pre-F IgG antibodies before RSV ARI support a potential role for pre-F IgG as a correlate of protection against RSV ARI. Induction of breast milk pre-F IgG may be a mechanism of protection for maternal RSV vaccines. Low breast milk prefusion (pre-F) immunoglobulin G (IgG) antibodies before respiratory syncytial virus (RSV) acute respiratory infection (ARI) supports a potential role for pre-F IgG as a correlate of protection against RSV ARI. Induction of breast milk pre-F IgG may be a mechanism of protection for maternal RSV vaccines.
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影响因子：
5.9
作者：
Hurley WL;Theil PK
通讯作者：
Theil PK
DOI：
10.1126/science.1234914
发表时间：
2013-05-31
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
McLellan JS;Chen M;Leung S;Graepel KW;Du X;Yang Y;Zhou T;Baxa U;Yasuda E;Beaumont T;Kumar A;Modjarrad K;Zheng Z;Zhao M;Xia N;Kwong PD;Graham BS
通讯作者：
Graham BS
影响因子：
9.4
作者：
Kuypers, Jane;Wright, Nancy;Morrow, Rhoda
通讯作者：
Morrow, Rhoda
DOI：
10.1056/nejmoa0804877
发表时间：
2009-02-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hall CB;Weinberg GA;Iwane MK;Blumkin AK;Edwards KM;Staat MA;Auinger P;Griffin MR;Poehling KA;Erdman D;Grijalva CG;Zhu Y;Szilagyi P
通讯作者：
Szilagyi P
影响因子：
6.4
作者：
Capella, Cristina;Chaiwatpongsakorn, Supranee;Peeples, Mark E.
通讯作者：
Peeples, Mark E.