A quantitative magnetic resonance histology atlas of postnatal rat brain development with regional estimates of growth and variability.
A quantitative magnetic resonance histology atlas of postnatal rat brain development with regional estimates of growth and variability.
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DOI：
10.1016/j.neuroimage.2013.01.017
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发表时间：
2013-05-01
期刊：
影响因子：
5.7
通讯作者：
Johnson GA
中科院分区：
文献类型：
--
作者：
Calabrese E;Badea A;Watson C;Johnson GA
出生后脑发育在几种神经系统疾病的病因学中的作用越来越受到关注。长期以来，大鼠一直被认为是研究神经病理学和药物治疗安全性的强大模型系统。然而，在大鼠神经发育过程中发生的复杂的时空变化仍有待阐明。这项工作建立了第一个磁共振组织学（MRH）发育中的大鼠大脑图谱，重点是定量。该图谱包括在9个时间点的每个时间点的5个样本，用8种不同的MR对比成像，并分割成26个发育定义的大脑区域。该图谱用于建立整个神经发育过程中形态学变化和变异性的时间轴，并代表用于表征人类神经疾病大鼠模型的大鼠神经发育的定量数据库。
There has been growing interest in the role of postnatal brain development in the etiology of several neurologic diseases. The rat has long been recognized as a powerful model system for studying neuropathology and the safety of pharmacologic treatments. However, the complex spatiotemporal changes that occur during rat neurodevelopment remain to be elucidated. This work establishes the first magnetic resonance histology (MRH) atlas of the developing rat brain, with an emphasis on quantitation. The atlas comprises five specimens at each of nine time points, imaged with eight distinct MR contrasts and segmented into 26 developmentally defined brain regions. The atlas was used to establish a timeline of morphometric changes and variability throughout neurodevelopment and represents a quantitative database of rat neurodevelopment for characterizing rat models of human neurologic disease.
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影响因子：
16.2
作者：
Giedd, Jay N.;Rapoport, Judith L.
通讯作者：
Rapoport, Judith L.
影响因子：
5.7
作者：
Calabrese E;Johnson GA;Watson C
通讯作者：
Watson C
影响因子：
2
作者：
HILLMAN, H;DEUTSCH, K
通讯作者：
DEUTSCH, K
影响因子：
--
作者：
Jackson, CM
通讯作者：
Jackson, CM
影响因子：
5.7
作者：
Avants BB;Tustison NJ;Song G;Cook PA;Klein A;Gee JC
通讯作者：
Gee JC