Structural MRI of pediatric brain development: what have we learned and where are we going?
Structural MRI of pediatric brain development: what have we learned and where are we going?
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DOI：
10.1016/j.neuron.2010.08.040
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发表时间：
2010-09-09
期刊：
影响因子：
16.2
通讯作者：
Rapoport, Judith L.
中科院分区：
文献类型：
--
作者：
Giedd, Jay N.;Rapoport, Judith L.
磁共振成像（MRI）允许前所未有的访问解剖和生理发育中的大脑，而不使用电离辐射。在过去的二十年里，已经获得了数千例健康青年和神经精神疾病患者的大脑MRI扫描，并在诊断，性别，遗传学和/或心理变量（如智商）方面进行了分析。最初的报告比较了不同年龄段大脑组成部分的平均大小差异，这引起了纵向研究，研究了随着时间的推移的发展轨迹，并对神经回路进行了评估，而不是孤立的结构。虽然MRI仍然不是常规的诊断工具，用于评估儿科神经精神疾病，典型与非典型发展的模式已经出现，可能阐明病理机制，并建议干预的目标。在这篇综述中，我们总结了结构MRI对我们理解健康和疾病中的神经发育的一般贡献。
Magnetic resonance imaging (MRI) allows unprecedented access to the anatomy and physiology of the developing brain without the use of ionizing radiation. Over the past two decades, thousands of brain MRI scans from healthy youth and those with neuropsychiatric illness have been acquired and analyzed with respect to diagnosis, sex, genetics, and/or psychological variables such as IQ. Initial reports comparing size differences of various brain components averaged across large age spans have given rise to longitudinal studies examining trajectories of development over time and evaluations of neural circuitry as opposed to structures in isolation. Although MRI is still not of routine diagnostic utility for evaluation of pediatric neuropsychiatric disorders, patterns of typical versus atypical development have emerged that may elucidate pathologic mechanisms and suggest targets for intervention. In this review we summarize general contributions of structural MRI to our understanding of neurodevelopment in health and illness.
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DOI：
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发表时间：
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影响因子：
11.1
作者：
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发表时间：
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影响因子：
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