First evidence of long-term effects of transcranial pulse stimulation (TPS) on the human brain.
First evidence of long-term effects of transcranial pulse stimulation (TPS) on the human brain.
复制标题
经颅脉冲刺激（TPS）对人脑的长期影响的第一个证据。
DOI：
10.1186/s12967-021-03222-5
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发表时间：
2022-01-15
影响因子：
7.4
通讯作者：
Beisteiner R
中科院分区：
文献类型：
--
作者：
Matt E;Kaindl L;Tenk S;Egger A;Kolarova T;Karahasanović N;Amini A;Arslan A;Sariçiçek K;Weber A;Beisteiner R
基于超声的脑刺激技术具有高空间分辨率和到达深部脑结构的潜力，为非侵入性治疗神经和精神疾病提供了新的机会。然而，人们对超声波脑刺激的长期效果知之甚少。采用纵向设计，我们全面研究了超声脑刺激诱导的神经调节，以提供对人类大脑和行为的长期影响的第一个假控制证据。12名健康的被试接受了3次假性和3次正确率的经颅脉冲刺激（TPS），重点是右手皮层体感觉表征。在假体和椎体TPS应用前后一周，进行全面的结构和功能静息状态MRI调查以及针对触觉空间辨别和感觉运动灵巧性的行为测试。与假手术相比，椎体TPS后皮质感觉运动网络的整体效率显著提高，表明受刺激的功能性脑网络上调。椎体TPS后左侧感觉运动区轴向弥散性下降，表明受刺激区域轴突状态改善。在最后一次刺激后的一周内，TPS增加了受刺激的左初级体感觉皮层和相邻感觉运动区的功能和结构耦合。这些发现表明，TPS诱导的神经可塑性变化超出了空间和时间刺激的范围，鼓励进一步的临床应用。
With the high spatial resolution and the potential to reach deep brain structures, ultrasound-based brain stimulation techniques offer new opportunities to non-invasively treat neurological and psychiatric disorders. However, little is known about long-term effects of ultrasound-based brain stimulation. Applying a longitudinal design, we comprehensively investigated neuromodulation induced by ultrasound brain stimulation to provide first sham-controlled evidence of long-term effects on the human brain and behavior. Twelve healthy participants received three sham and three verum sessions with transcranial pulse stimulation (TPS) focused on the cortical somatosensory representation of the right hand. One week before and after the sham and verum TPS applications, comprehensive structural and functional resting state MRI investigations and behavioral tests targeting tactile spatial discrimination and sensorimotor dexterity were performed. Compared to sham, global efficiency significantly increased within the cortical sensorimotor network after verum TPS, indicating an upregulation of the stimulated functional brain network. Axial diffusivity in left sensorimotor areas decreased after verum TPS, demonstrating an improved axonal status in the stimulated area. TPS increased the functional and structural coupling within the stimulated left primary somatosensory cortex and adjacent sensorimotor areas up to one week after the last stimulation. These findings suggest that TPS induces neuroplastic changes that go beyond the spatial and temporal stimulation settings encouraging further clinical applications.
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影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
影响因子：
2.4
作者：
Lee W;Chung YA;Jung Y;Song IU;Yoo SS
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Yoo SS
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Mayo, Chantel D.;Garcia-Barrera, Mauricio A.;Gawryluk, Jodie R.
通讯作者：
Gawryluk, Jodie R.
影响因子：
4.8
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通讯作者：
Jaencke, Lutz
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作者：
Archer, Derek B.;Vaillancourt, David E.;Coombes, Stephen A.
通讯作者：
Coombes, Stephen A.