Simultaneous acoustic stimulation of human primary and secondary somatosensory cortices using transcranial focused ultrasound.
Simultaneous acoustic stimulation of human primary and secondary somatosensory cortices using transcranial focused ultrasound.
复制标题
DOI：
10.1186/s12868-016-0303-6
复制
发表时间：
2016-10-26
期刊：
影响因子：
2.4
通讯作者：
Yoo SS
中科院分区：
文献类型：
--
作者：
Lee W;Chung YA;Jung Y;Song IU;Yoo SS
经颅聚焦超声（FUS）作为一种新型的非侵入性脑刺激方法，与经颅磁刺激或经颅直流电刺激相比，具有上级空间分辨率和深度穿透的潜力。我们研究了存在的触觉引起的FUS刺激的两个独立的大脑区域在人类的主要（SI）和次要（SII）体感区的手，指导个人特定的功能磁共振成像数据。在图像引导下，分别或同时向SI和SII区域提供声刺激。SII区被分为子区域，这些子区域由右手手掌侧的四种外部触觉激活-振动触觉、压力、温暖和凉爽。在整个刺激条件下（仅SI，仅SII，SI和SII同时），参与者报告了从刺激对侧的手产生的各种类型的触觉，例如手掌/手背或单个/相邻手指。触觉感觉的类型与SII中特定子区域相关的感觉不匹配。FUS的神经刺激效应是短暂的和可逆的，并且该手术未引起受试者精神/身体状态的任何不良变化或不适。使用多个FUS换能器允许在同一半球中同时刺激SI/SII，并且在没有任何外部感官刺激的情况下引起各种触觉。单独刺激SII区域也可以诱导触觉感知。以空间受限的方式刺激多个大脑区域的能力可用于研究区域大脑活动与其认知/行为结果之间的因果关系。本文的在线版本（doi：10.1186/s12868-016-0303-6）包含补充材料，可供授权用户使用。
Transcranial focused ultrasound (FUS) is gaining momentum as a novel non-invasive brain stimulation method, with promising potential for superior spatial resolution and depth penetration compared to transcranial magnetic stimulation or transcranial direct current stimulation. We examined the presence of tactile sensations elicited by FUS stimulation of two separate brain regions in humans—the primary (SI) and secondary (SII) somatosensory areas of the hand, as guided by individual-specific functional magnetic resonance imaging data. Under image-guidance, acoustic stimulations were delivered to the SI and SII areas either separately or simultaneously. The SII areas were divided into sub-regions that are activated by four types of external tactile sensations to the palmar side of the right hand—vibrotactile, pressure, warmth, and coolness. Across the stimulation conditions (SI only, SII only, SI and SII simultaneously), participants reported various types of tactile sensations that arose from the hand contralateral to the stimulation, such as the palm/back of the hand or as single/neighboring fingers. The type of tactile sensations did not match the sensations that are associated with specific sub-regions in the SII. The neuro-stimulatory effects of FUS were transient and reversible, and the procedure did not cause any adverse changes or discomforts in the subject’s mental/physical status. The use of multiple FUS transducers allowed for simultaneous stimulation of the SI/SII in the same hemisphere and elicited various tactile sensations in the absence of any external sensory stimuli. Stimulation of the SII area alone could also induce perception of tactile sensations. The ability to stimulate multiple brain areas in a spatially restricted fashion can be used to study causal relationships between regional brain activities and their cognitive/behavioral outcomes. The online version of this article (doi:10.1186/s12868-016-0303-6) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
158.5
作者：
Elias, W. Jeffrey;Huss, Diane;Wintermark, Max
通讯作者：
Wintermark, Max
影响因子：
10.6
作者：
Fitzpatrick, JM;West, JB
通讯作者：
West, JB
影响因子：
3.3
作者：
Collins, CM;Smith, MB;Turner, R
通讯作者：
Turner, R
影响因子：
7.7
作者：
Kim H;Chiu A;Lee SD;Fischer K;Yoo SS
通讯作者：
Yoo SS
影响因子：
9.2
作者：
Deffieux, Thomas;Younan, Youliana;Aubry, Jean-Francois
通讯作者：
Aubry, Jean-Francois