Neurological manifestations of COVID-19: a systematic review and meta-analysis of proportions.
Neurological manifestations of COVID-19: a systematic review and meta-analysis of proportions.
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DOI：
10.1007/s10072-020-04801-y
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发表时间：
2020-12
期刊：
影响因子：
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通讯作者：
Pathak A
中科院分区：
文献类型：
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作者：
Favas TT;Dev P;Chaurasia RN;Chakravarty K;Mishra R;Joshi D;Mishra VN;Kumar A;Singh VK;Pandey M;Pathak A
冠状病毒主要影响呼吸系统；然而，有报道称 SARS-CoV 和 MERS-CoV 会引起神经系统症状。我们的目的是讨论 SARS-CoV-2 感染的各种神经学表现并估计每种表现的患病率。我们检索了以下电子数据库； PubMed、MEDLINE、Scopus、EMBASE、Google Scholar、EBSCO、Web of Science、Cochrane 图书馆、WHO 数据库和 ClinicalTrials.gov。使用了 COVID-19 和神经系统表现的相关 MeSH 术语。该研究包括随机对照试验、非随机对照试验、病例对照研究、队列研究、横断面研究、病例系列和病例报告。为了估计每种神经系统表现的总体比例，该研究利用随机效应模型对比例进行了荟萃分析。每种神经系统表现的汇总患病率是：嗅觉障碍（35.8%；95% CI 21.4–50.2）、味觉障碍（38.5%；95% CI 24.0–53.0）、肌痛（19.3%；95% CI 15.1–23.6）、头痛（14.7%；95% CI 10.4–18.9）、头晕（6.1%；95% CI 3.1–9.2）和晕厥（1.8%；95% CI 0.9–4.6）。急性脑血管疾病的汇总患病率为（2.3%；95% CI 1.0-3.6），其中大多数为缺血性卒中（2.1%；95% CI 0.9-3.3），其次是出血性卒中（0.4%；95% CI 0.2-0.6）和脑静脉血栓形成（0.3%；95% CI） 0.1–0.6）。神经系统症状在 SARS-CoV-2 感染中很常见，从世界各地每天报告的大量病例来看，神经系统症状的患病率可能会再次增加。识别嗅觉和味觉障碍等一些神经系统表现可用于筛查 COVID-19 患者，以便尽早识别和隔离。
Coronaviruses mainly affect the respiratory system; however, there are reports of SARS-CoV and MERS-CoV causing neurological manifestations. We aimed at discussing the various neurological manifestations of SARS-CoV-2 infection and to estimate the prevalence of each of them. We searched the following electronic databases; PubMed, MEDLINE, Scopus, EMBASE, Google Scholar, EBSCO, Web of Science, Cochrane Library, WHO database, and ClinicalTrials.gov. Relevant MeSH terms for COVID-19 and neurological manifestations were used. Randomized controlled trials, non-randomized controlled trials, case-control studies, cohort studies, cross-sectional studies, case series, and case reports were included in the study. To estimate the overall proportion of each neurological manifestations, the study employed meta-analysis of proportions using a random-effects model. Pooled prevalence of each neurological manifestations are, smell disturbances (35.8%; 95% CI 21.4–50.2), taste disturbances (38.5%; 95%CI 24.0–53.0), myalgia (19.3%; 95% CI 15.1–23.6), headache (14.7%; 95% CI 10.4–18.9), dizziness (6.1%; 95% CI 3.1–9.2), and syncope (1.8%; 95% CI 0.9–4.6). Pooled prevalence of acute cerebrovascular disease was (2.3%; 95%CI 1.0–3.6), of which majority were ischaemic stroke (2.1%; 95% CI 0.9–3.3), followed by haemorrhagic stroke (0.4%; 95% CI 0.2–0.6), and cerebral venous thrombosis (0.3%; 95% CI 0.1–0.6). Neurological symptoms are common in SARS-CoV-2 infection, and from the large number of cases reported from all over the world daily, the prevalence of neurological features might increase again. Identifying some neurological manifestations like smell and taste disturbances can be used to screen patients with COVID-19 so that early identification and isolation is possible.
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影响因子：
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作者：
Bagheri SH;Asghari A;Farhadi M;Shamshiri AR;Kabir A;Kamrava SK;Jalessi M;Mohebbi A;Alizadeh R;Honarmand AA;Ghalehbaghi B;Salimi A;Dehghani Firouzabadi F
通讯作者：
Dehghani Firouzabadi F
影响因子：
2.4
作者：
Al-olama, Mohammad;Rashid, Anas;Garozzo, Debora
通讯作者：
Garozzo, Debora
影响因子：
15.9
作者：
Chen, Guang;Wu, Di;Ning, Qin
通讯作者：
Ning, Qin
影响因子：
9.9
作者：
Benussi, Alberto;Pilotto, Andrea;Padovani, Alessandro
通讯作者：
Padovani, Alessandro
DOI：
10.15585/mmwr.mm6915e6
发表时间：
2020-04-17
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
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作者：
CDC COVID-19 Response Team
通讯作者：
CDC COVID-19 Response Team