Oral Probiotics Ameliorate the Behavioral Deficits Induced by Chronic Mild Stress in Mice via the Gut Microbiota-Inflammation Axis.
Oral Probiotics Ameliorate the Behavioral Deficits Induced by Chronic Mild Stress in Mice via the Gut Microbiota-Inflammation Axis.
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DOI：
10.3389/fnbeh.2018.00266
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发表时间：
2018
影响因子：
3
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Li N;Wang Q;Wang Y;Sun A;Lin Y;Jin Y;Li X
近年来，大量研究揭示了抑郁症与肠道微生物群之间的联系，从而导致益生菌用于治疗压力相关疾病。在这项研究中，我们探索了多菌株益生菌治疗（瑞士乳杆菌 R0052、植物乳杆菌 R1012 和长双歧杆菌 R0175）在慢性轻度应激 (CMS) 抑郁症小鼠模型中的潜在抗抑郁功效，并确定了其可能的作用机制。我们的研究结果显示，接受CMS的小鼠在蔗糖偏好测试、高架十字迷宫和强迫游泳测试中表现出焦虑和抑郁样行为，同时海马中干扰素-γ、肿瘤坏死因子-α和吲哚胺2,3-双加氧酶-1水平增加。此外，微生物群与非应激组相比发生了明显变化，其特征是高度多样化的细菌群落，与乳酸杆菌种类的显着减少有关。益生菌减弱了 CMS 引起的焦虑和抑郁样行为，显着增加了乳酸菌丰度，并逆转了 CMS 引起的海马免疫变化。因此，益生菌抗抑郁样活性的可能机制通过肠道微生物群-炎症-大脑轴与乳酸菌物种相关。
In recent years, a burgeoning body of research has revealed links between depression and the gut microbiota, leading to the therapeutic use of probiotics for stress-related disorders. In this study, we explored the potential antidepressant efficacy of a multi-strain probiotics treatment (Lactobacillus helveticus R0052, Lactobacillus plantarum R1012, and Bifidobacterium longum R0175) in a chronic mild stress (CMS) mouse model of depression and determined its probable mechanism of action. Our findings revealed that mice subjected to CMS exhibited anxiety- and depressive-like behaviors in the sucrose preference test, elevated plus maze, and forced swim test, along with increased interferon-γ, tumor necrosis factor-α, and indoleamine 2,3-dioxygenase-1 levels in the hippocampus. Moreover, the microbiota distinctly changed from the non-stress group and was characterized by highly diverse bacterial communities associated with significant reductions in Lactobacillus species. Probiotics attenuated CMS-induced anxiety- and depressive-like behaviors, significantly increased Lactobacillus abundance, and reversed the CMS-induced immune changes in the hippocampus. Thus, the possible mechanism involved in the antidepressant-like activity of probiotics is correlated with Lactobacillus species via the gut microbiota-inflammation-brain axis.
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影响因子：
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