Regenerative Medicine and Immunomodulatory Therapy: Insights From the Kidney, Heart, Brain, and Lung.

Regenerative Medicine and Immunomodulatory Therapy: Insights From the Kidney, Heart, Brain, and Lung.
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DOI:
10.1016/j.ekir.2017.12.012
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发表时间:
2018-07
影响因子:
6
通讯作者:
Humes HD
Humes HD
中科院分区:
医学2区
文献类型:
--
作者:
Pino CJ;Westover AJ;Johnston KA;Buffington DA;Humes HD

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再生医学最初专注于组织工程,用细胞和生物材料构建替代受损组织和器官。最近,这一领域的研究已经扩展到令人兴奋的转化医学领域,即调节人体自身的内源性过程,以防止器官组织损伤,并修复和再生这些受损组织。这篇综述将集中在最近的研究中得出的见解,这些研究表明,操纵先天免疫系统可能会减少急性肾损伤,增强肾脏修复和恢复,而不会发展为慢性肾脏疾病和肾功能衰竭。这些干预措施可能改善急性和慢性器官功能障碍的方式,包括心脏、大脑和肺,也将进行审查。
Regenerative medicine was initially focused on tissue engineering to replace damaged tissues and organs with constructs derived from cells and biomaterials. More recently, this field of inquiry has expanded into exciting areas of translational medicine modulating the body’s own endogenous processes, to prevent tissue damage in organs and to repair and regenerate these damaged tissues. This review will focus on recent insights derived from studies in which the manipulation of the innate immunologic system may diminish acute kidney injury and enhance renal repair and recovery without the progression to chronic kidney disease and renal failure. The manner in which these interventions may improve acute and chronic organ dysfunction, including the heart, brain, and lung, will also be reviewed.
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