Reorganization of CA1 dendritic dynamics by hippocampal sharp-wave ripples during learning.
Reorganization of CA1 dendritic dynamics by hippocampal sharp-wave ripples during learning.
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DOI：
10.1016/j.neuron.2021.12.017
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发表时间：
2022-03-16
期刊：
影响因子：
16.2
通讯作者：
Losonczy A
中科院分区：
文献类型：
--
作者：
Rolotti SV;Blockus H;Sparks FT;Priestley JB;Losonczy A
海马在记忆巩固中起着关键作用，在尖波涟漪（SWR）事件期间通过协调网络活动介导。尽管SWRs和海马可塑性之间的联系，很少有人知道网络状态如何影响树突，突触输入整合和可塑性的主要网站的信息处理。在这里，我们监测体细胞和基础树突状细胞在CA 1锥体细胞的行为小鼠使用纵向双光子钙成像集成与同步局部场电位记录。我们发现不动性与集中在SWR期间树突活动的增加有关。一致的树突和体细胞的活动在SWR预测增加耦合在随后的探索一个新的环境。相反，在目标学习任务中，体细胞-树突耦合和SWR募集随细胞到奖励位置的调谐距离而变化。我们的研究结果连接SWRs与稳定的CA 1神经元内的信息处理，并建议这些机制可能是动态偏置的行为需求。Rolotti等人结合联合收割机钙成像和电生理学研究小鼠海马体中跨行为和网络状态的体细胞-树突动力学。尖波波纹调制树突的活动，诱导长期的变化，体细胞树突耦合。强化改变涟漪招聘和解离树突体细胞的空间调谐。涟漪可以促进树突重组以稳定海马计算。
The hippocampus plays a critical role in memory consolidation, mediated by coordinated network activity during sharp wave ripple (SWR) events. Despite the link between SWRs and hippocampal plasticity, little is known about how network state affects information processing in dendrites, the primary sites of synaptic input integration and plasticity. Here we monitored somatic and basal dendritic activity in CA1 pyramidal cells in behaving mice using longitudinal two-photon calcium imaging integrated with simultaneous local field potential recordings. We found immobility was associated with an increase in dendritic activity concentrated during SWRs. Coincident dendritic and somatic activity during SWRs predicted increased coupling during subsequent exploration of a novel environment. In contrast, somatic-dendritic coupling and SWR recruitment varied with cells’ tuning distance to reward location during a goal-learning task. Our results connect SWRs with the stabilization of information processing within CA1 neurons and suggest these mechanisms may be dynamically biased by behavioral demands. Rolotti et al. combine calcium imaging and electrophysiology to study somatic-dendritic dynamics across behavior and network states in mouse hippocampus. Sharp wave ripples modulate dendritic activity, inducing long-term changes in soma-dendrite coupling. Reinforcement alters ripple recruitment and dissociates dendritic-somatic spatial tuning. Ripples may facilitate dendritic reorganization to stabilize hippocampal computations.
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