Hippocampal replay in the awake state: a potential substrate for memory consolidation and retrieval.
Hippocampal replay in the awake state: a potential substrate for memory consolidation and retrieval.
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DOI：
10.1038/nn.2732
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发表时间：
2011-02
影响因子：
25
通讯作者：
Frank, Loren M.
中科院分区：
文献类型：
--
作者：
Carr, Margaret F.;Jadhav, Shantanu P.;Frank, Loren M.
海马体是事件记忆的编码、巩固和提取所必需的。虽然这些过程背后的神经机制只被部分理解，但最近的一系列论文指出，清醒记忆重放是巩固和提取的潜在贡献者。重放是海马位置细胞的顺序再激活，其代表先前经历的行为轨迹，并且经常在清醒状态下发生，特别是在相对不动的时期。唤醒重放可以反映通过当前环境或空间上远程的先前访问的环境的轨迹。在压缩的时间尺度上重复学习序列非常适合促进海马体以外的分布式回路中的记忆巩固，这表明巩固发生在清醒和睡眠的动物中。此外，感官信息可以影响清醒重放的内容，这表明清醒重放在记忆提取中的作用。
The hippocampus is required for the encoding, consolidation, and retrieval of event memories. While the neural mechanisms that underlie these processes are only partially understood, a series of recent papers point to awake memory replay as a potential contributor to both consolidation and retrieval. Replay is the sequential reactivation of hippocampal place cells that represent previously experienced behavioral trajectories and occurs frequently in the awake state, particularly during periods of relative immobility. Awake replay may reflect trajectories through either the current environment or previously visited environments that are spatially remote. The repetition of learned sequences on a compressed time scale is well suited to promote memory consolidation in distributed circuits beyond the hippocampus, suggesting that consolidation occurs in both the awake and sleeping animal. Moreover, sensory information can influence the content of awake replay, suggesting a role for awake replay in memory retrieval.
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影响因子：
25
作者：
Dupret, David;O'Neill, Joseph;Pleydell-Bouverie, Barty;Csicsvari, Jozsef
通讯作者：
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25
作者：
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作者：
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