The brain on stress: vulnerability and plasticity of the prefrontal cortex over the life course.
The brain on stress: vulnerability and plasticity of the prefrontal cortex over the life course.
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DOI：
10.1016/j.neuron.2013.06.028
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发表时间：
2013-07-10
期刊：
影响因子：
16.2
通讯作者：
Morrison JH
中科院分区：
文献类型：
--
作者：
McEwen BS;Morrison JH
前额叶皮层（prefrontal cortex，PFC）参与工作记忆、自我调节和目标导向行为，并在生命过程中表现出显著的结构和功能可塑性。神经回路、分子特征和神经化学可以通过经验改变，这影响行为以及神经内分泌和自主神经功能。这种影响在婴儿期和青春期尤其严重。行为应激会影响PFC的结构和功能，尽管这种影响不一定是永久性的，因为如果应激停止，年幼的动物表现出显着的神经元弹性。在衰老过程中，PFC内的神经元对压力的适应力变得更弱。前额叶皮层对压力的反应也存在性别差异。虽然这种压力和性激素相关的改变发生在介导最高水平的认知功能和自我调节控制的区域，但它们不一定是永久性的，这一事实对未来利用神经可塑性进行恢复的基于行为的疗法具有影响。
The prefrontal cortex (PFC) is involved in working memory, self-regulatory and goal-directed behaviors and displays remarkable structural and functional plasticity over the life course. Neural circuitry, molecular profiles and neurochemistry can be changed by experiences, which influences behavior as well as neuroendocrine and autonomic function. Such effects have a particular impact during infancy and in adolescence. Behavioral stress affects both the structure and function of PFC, though such effects are not necessarily permanent, as young animals show remarkable neuronal resilience if the stress is discontinued. During aging, neurons within the PFC become less resilient to stress. There are also sex differences in the PFC response to stressors. While such stress- and sex-hormone related alterations occur in regions mediating the highest levels of cognitive function and self regulatory control, the fact that they are not necessarily permanent has implications for future behavior-based therapies that harness neural plasticity for recovery.
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影响因子：
10.6
作者：
Ansell, Emily B.;Rando, Kenneth;Tuit, Keri;Guarnaccia, Joseph;Sinha, Rajita
通讯作者：
Sinha, Rajita
DOI：
10.1523/jneurosci.0759-10.2010
发表时间：
2010-05-12
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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作者：
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通讯作者：
Morrison JH
影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
2.5
作者：
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通讯作者：
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