Melanization of Cryptococcus neoformans in murine infection.
Melanization of Cryptococcus neoformans in murine infection.
复制标题
小鼠感染中新型隐球菌的黑化。
DOI：
10.1128/mcb.19.1.745
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发表时间：
1999
影响因子：
5.3
通讯作者：
Casadevall,A
中科院分区：
文献类型：
--
作者：
Nosanchuk,JD;Valadon,P;Feldmesser,M;Casadevall,A
Cryptococcus neoformansis a fungus that is pathogenic in humans and that can produce melanin in vitro. Melanization is associated with virulence, but there is no evidence that melanin is made during infection. Melanins are difficult to study because they are amorphous and insoluble. Melanin-binding peptides from a phage display library were used to demonstrate thatC. neoformansmakes melanin-like compounds in tissue. Melanin-binding peptides were characterized by a high proportion of positively charged and aromatic residues. Two other methods, demonstration of an antibody response to melanin in mice infected withC. neoformansand analysis of yeast cell walls in infected tissue by light microscopy, were used to support these findings. The demonstration thatC. neoformansmelanizes in tissue has important implications for pathogenesis and drug discovery.
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影响因子：
4.4
作者：
M. Feldmesser;Arturo Casadevall
通讯作者：
M. Feldmesser;Arturo Casadevall
新型隐球菌中的黑色素生成。
DOI：
10.1099/00221287-134-4-1037
发表时间：
1988
期刊：
Journal of general microbiology
影响因子：
--
作者：
Itzhack Polacheck;K. Kwon
通讯作者：
K. Kwon
DOI：
10.1016/0304-4165(92)90121-a
发表时间：
1992
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
M. Porebska;N. Sakina;K. Stępień;A. Dontsov;T. Wilczok
通讯作者：
T. Wilczok
影响因子：
3.5
作者：
PARMLEY, SF;SMITH, GP
通讯作者：
SMITH, GP
DOI：
10.3109/02841868609136368
发表时间：
1986
期刊：
Acta radiologica. Oncology
影响因子：
--
作者：
E. Rofstad
通讯作者：
E. Rofstad