Risk factors associated with within-herd transmission of bovine leukemia virus on dairy farms in Japan.
Risk factors associated with within-herd transmission of bovine leukemia virus on dairy farms in Japan.
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DOI：
10.1186/1746-6148-6-1
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发表时间：
2010-01-07
影响因子：
2.6
通讯作者：
Murakami K
中科院分区：
文献类型：
--
作者：
Kobayashi S;Tsutsui T;Yamamoto T;Hayama Y;Kameyama K;Konishi M;Murakami K
虽然已经在地方一级进行了几次控制地方性牛白血病（EBL）的尝试，但除了被动监测外，日本还没有实施全国性的控制计划。有效控制牛白血病病毒感染需要在科学证据的基础上查明和阻断牛白血病病毒（BLV）的传播途径。在这项横断面研究中，我们研究了与日本受感染奶牛场BLV群内传播相关的风险因素。采用酶联免疫吸附试验（ELISA）对139个奶牛场随机抽取的30头成年奶牛的血样进行了检测。使用结构化问卷收集牛群管理信息。受感染的农场定义为有一只以上ELISA阳性动物的农场，占研究中139个农场中的110个（79.1%）。从这110个农场中的90个农场获得的完整问卷用于统计分析。血清阳性率（定义为在农场检测的所有动物中检测为阳性的动物比例）在第25、50和75个批次分别为17.1%、48.1%和68.5%。混合Logistic回归分析显示，松散的住房制度、去角和夏季大量马蝇是危险因素（系数= 0.71、1.11和0.82; p = 0.03，< 0.01，和0.01），并将其母兽的初乳作为保护因素饲喂新生小牛（系数=-1.11，p = 0.03），防止BLV在感染农场的农场内传播。通过特别关注这些风险和保护因素，将改善日本受感染奶牛场的EBL控制。
Although several attempts have been made to control enzootic bovine leukosis (EBL) at the local level, a nationwide control program has not been implemented in Japan, except for passive surveillance. Effective control of EBL requires that the transmission routes of bovine leukemia virus (BLV) infection should be identified and intercepted based on scientific evidence. In this cross-sectional study, we examined the risk factors associated with within-herd transmission of BLV on infected dairy farms in Japan. Blood samples taken from 30 randomly selected adult cows at each of 139 dairy farms were tested by enzyme-linked immunosorbent assay (ELISA). Information on herd management was collected using a structured questionnaire. Infected farms were defined as those with more than one ELISA-positive animal and accounted for 110 (79.1%) of the 139 farms in the study. Completed questionnaires obtained from 90 of these 110 farms were used for statistical analysis. Seroprevalence, which was defined as the proportions of animals that tested positive out of all animals tested on the farm, was 17.1%, 48.1%, and 68.5% for the 25th, 50th, and 75th percentiles, respectively. A mixed logistic regression analysis implicated a loose housing system, dehorning, and a large number of horseflies in summer as risk factors (coefficient = 0.71, 1.11, and 0.82; p = 0.03, < 0.01, and 0.01, respectively) and feeding of colostrum to newborn calves from their dams as a protective factor (coefficient = -1.11, p = 0.03) against within-farm transmission of BLV on infected farms. Control of EBL in infected dairy farms in Japan will be improved by focusing particularly on these risk and protective factors.
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影响因子：
2.6
作者：
Acaite, J.;Tamosiunas, V.;Pieskus, J.
通讯作者：
Pieskus, J.
影响因子：
56.9
作者：
FERRER, JF;KENYON, SJ;GUPTA, P
通讯作者：
GUPTA, P
影响因子：
2.2
作者：
HOPKINS, SG;EVERMANN, JF;BANGERT, RL
通讯作者：
BANGERT, RL
影响因子：
6.4
作者：
KONO, Y;SENTSUI, H;SAKAMOTO, Y
通讯作者：
SAKAMOTO, Y
影响因子：
2.6
作者：
Ott, SL;Johnson, R;Wells, SJ
通讯作者：
Wells, SJ