Increases in helper induced T cells and activated T cells in HTLV‐I–associated myelopathy
Increases in helper induced T cells and activated T cells in HTLV‐I–associated myelopathy
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HTLV-I 相关脊髓病中辅助诱导 T 细胞和活化 T 细胞的增加
DOI：
10.1002/ana.410260212
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发表时间：
1989
影响因子：
11.2
通讯作者：
N. Yamamoto
中科院分区：
文献类型：
--
作者：
Y. Itoyama;J. Kira;N. Fujii;I. Goto;N. Yamamoto
使用双色流式细胞术分析，我们研究了 15 名人类 T 细胞嗜淋巴细胞病毒 I 型相关脊髓病患者的外周血淋巴细胞亚群。与 16 名人类 T 细胞嗜淋巴细胞病毒 I 型血清阴性的健康对照受试者相比，脊髓病患者的 CD 4+4B4+ 细胞（辅助诱导 T 细胞）百分比显着增加。然而，两组之间 CD4+2H4+ 细胞（抑制诱导 T 细胞）的百分比没有差异。这些患者中 CD4+4B4+ 细胞与 CD4+ 细胞的比率以及 CD4+4B4+ 与 CD4+ 2H4+ 细胞的比率也升高。与对照组相比，患者的CD4+DR+细胞和CD8+DR+细胞（均为表型激活的T细胞）的百分比以及CD4+DR+细胞与CD4+细胞的比率以及CD8+DR+细胞与CD8+细胞的比率也有所增加。脊髓病患者Cd4+4B4+细胞百分比与外周血淋巴细胞自发增殖值及血清IgG水平呈正相关。
Using two‐color flow cytometric analysis, we studied peripheral blood lymphocyte subsets in 15 patients with human T‐cell lymphotropic virus type I–associated myelopathy. The percentage of CD 4+4B4+ cells (helper inducer T cell) was significantly increased in the patients with the myelopathy, compared with 16 healthy control subjects who were seronegative for human T‐cell lymphotropic virus type I. However, there was no difference in the percentage of CD4+2H4+ cells (suppressor inducer T cell) between the two groups. The ratio of CD4+4B4+ cells to CD4+ cells and CD4+4B4+ to CD4+ 2H4+ cells was also elevated in these patients. The percentage of CD4+DR+ cells and CD8+DR+ cells, both of which are phenotypically activated T cells, and the ratio of CD4+DR+ cells to CD4+ cells and of CD8+DR+ cells to CD8+ cells are also increased in the patients, compared with the control subjects. The percentage of Cd4+4B4+ cells showed positive correlations with values of spontaneous proliferation of peripheral blood lymphocytes and serum IgG level in patients with the myhelopathy.
类风湿关节中辅助诱导剂的增加和抑制诱导剂表型的减少。
影响因子：
--
作者：
Lasky,HP;Bauer,K;Pope,RM
通讯作者：
Pope,RM
进行性多发性硬化症中抑制-诱导 T 细胞亚群的选择性丧失。
DOI：
10.1056/nejm198701083160202
发表时间：
1987
期刊：
The New England journal of medicine
影响因子：
--
作者：
Morimoto,C;Hafler,DA;Weiner,HL;Letvin,NL;Hagan,M;Daley,J;Schlossman,SF
通讯作者：
Schlossman,SF
人类抑制诱导 T 细胞亚群的分离和表征。
DOI：
--
发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Morimoto,C;Letvin,NL;Distaso,JA;Aldrich,WR;Schlossman,SF
通讯作者：
Schlossman,SF