Induced and natural variation of promoter length modulates the photoperiodic response of FLOWERING LOCUS T.
Induced and natural variation of promoter length modulates the photoperiodic response of FLOWERING LOCUS T.
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DOI：
10.1038/ncomms5558
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发表时间：
2014-08-04
影响因子：
16.6
通讯作者：
Turck, Franziska
中科院分区：
文献类型：
--
作者：
Liu, Liangyu;Adrian, Jessika;Pankin, Artem;Hu, Jinyong;Dong, Xue;von Korff, Maria;Turck, Franziska
花座T（FT）通过整合环境季节信号和内部线索来调节许多植物物种的花转变。在这里，我们表明，两个相互依赖的调节区域是必要的，足以传达光周期响应FT。虽然需要调节区之间的最小距离以在短日照下完全抑制FT表达，但是增加的距离降低了启动子对长日照的响应。在FT创建启动子长度差异的自然变化是广泛的，与纵向和横向的倾斜，并影响物理上与两个光周期控制区相互作用的启动子区域。三个主要的FT启动子变异与F1杂种中FT等位基因使用的差异相关。我们建议，FT的变化在顺式可能是自适应的，通过赋予FT转录控制的差异，最终转化为增加健身。 在许多植物中，FLOWERY LOCUS T的基因表达控制着花的转变，并受到环境信号和内部线索的调节。Liu等人表明，FT启动子中两个调控序列之间的距离随地理位置而变化，并决定对光周期的响应。
FLOWERING LOCUS T (FT) regulates the floral transition in many plant species by integrating environmental seasonal signals and internal cues. Here we show that two interdependent regulatory regions are necessary and sufficient to convey photoperiod responsiveness to FT. While a minimal distance between the regulatory regions is required to fully suppress FT expression under short days, increased distance reduces promoter response to long days. Natural variation at FT creating promoter length differences is widespread, correlates with longitudinal and latitudinal clines and affects a promoter region physically interacting with both photoperiod control regions. Three major FT promoter variants correlate with differences in FT allele usage in F1 hybrids. We propose that FT variation in cis could be adaptive by conferring differences in FT transcriptional control ultimately translating to increased fitness. Gene expression at FLOWERING LOCUS T controls floral transition in many plants and is regulated by both environmental signals and internal cues. Liu et al. show that the distance between two regulatory sequences in the FT promoter varies with geographical location and determines responsiveness to photoperiod.
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